Author: SRI International
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Blockade of α6* nAChR Reduces L-Dopa-Induced Dyskinesias; Studies Using Parkinsonian α6* nAChR Gain-of-Function Mice
To understand the mechanism through which α6β2* nAChRs regulate L-dopa-induced AIMs, we used gain-of-function α6* nAChR (α6L9’S) mice. This mutation results in enhanced sensitivity to nicotine/acetylcholine and prolonged receptor-mediated activity.
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Estimating the Vector Electric Field Using Monostatic, Multibeam Incoherent Scatter Radar Measurements
An algorithm has been developed to image the local structure in the convection electric field using multibeam incoherent scatter radar (ISR) data.
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Question Generation from a Knowledge Base
We present a technique for responding to natural language questions, by suggesting a series of questions that the system can actually answer. We also show that the suggested questions are useful in a variety of ways in an intelligent textbook to improve student learning.
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Inconsistency Monitoring in a Large Scientific Knowledge Base
We describe our approach for inconsistency monitoring in a large biology KB.
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USP8 Regulates Mitophagy by Removing K6-Linked Ubiquitin Conjugates from Parkin
We report here that USP8/UBPY, a deubiquitinating enzyme not previously implicated in mitochondrial quality control, is critical for parkin-mediated mitophagy.
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Modification of the Loss Cone for Energetic Particles
The optimal pitch angle which maximizes the penetration distance, along the magnetic field, of relativistic charged particles injected from the midplane of an axisymmetric field is investigated analytically and numerically.
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Evidence of Reporting Biases in Voxel-Based Morphometry (VBM) Studies of Psychiatric and Neurological Disorders
Objective: To evaluate whether biases may influence the findings of whole-brain structural imaging literature.
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Radar Detectability Studies of Slow and Small Zodiacal Dust Cloud Particles. I. The Case of Arecibo 430 MHz Meteor Head Echo Observations
In this paper, we present a new methodology utilizing meteor head echo radar observations that aims to constrain the ZDC physical model by ground-based measurements.
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The Effect of Solar Flares, Coronal Mass Ejections, and Solar Wind Streams on Venus’ 5577 Angstrom Oxygen Green Line
We observed the Venusian 5577.3 Å OI nightglow emission feature after solar flares, coronal mass ejections, and solar wind streams from December 2010 to July 2012 using the high resolution Astrophysical Research Consortium Echelle Spectrograph.
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Control Systems Security from the Front Lines
As part of this special issue on control systems for the energy sector, guest editors Sean Peisert and Jonathan Margulies put together a roundtable discussion so readers can learn about the security challenges facing the industrial control system/SCADA world from those who are on the front lines.
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Evaluation of OMI Operational Standard NO2 Column Retrievals Using in Situ and Surface-Based NO2 Observations
We assess the standard operational nitrogen dioxide data product retrieved from the Ozone Monitoring Instrument onboard NASA’s Aura satellite using a combination of aircraft and surface in situ measurements.
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Folate and Vitamin B12 May Play a Critical Role in Lowering the HPV 16 Methylation-Associated Risk of Developing Higher Grades of CIN
The purpose of the current study was to replicate our previous findings and to evaluate the influence of plasma concentrations of folate and vitamin B12 on the degree of HPV 16 methylation (HPV 16m).