Author: SRI International
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Blocking the B7-H4 Pathway with Novel Recombinant Antibodies Enhances T Cell-Mediated Antitumor Responses
We have recently demonstrated that the expression of B7-H4 on the surface of malignant cells in vivo is inducible, and that novel anti-B7-H4 recombinant antibodies can reverse the inhibition of tumor-specific T cells.
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Alpha4beta2 Nicotinic Receptors Play a Role in the nAChR-Mediated Decline in l-Dopa-Induced Dyskinesias in Parkinsonian Rats
The present experiments were done to determine if alpha4beta2* nAChRs are also involved in l-dopa-induced dyskinesias. Since alpha4alpha5beta2 nAChRs are also predominantly on striatal dopamine terminals, these data suggest that drugs targeting alpha4beta2 nAChRs may reduce l-dopa-induced dyskinesias in late stage Parkinson’s disease.
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Development and Test of an Active Pixel Sensor Detector for Heliospheric Imager on Solar Orbiter and Solar Probe Plus
The devices are robust (
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The Solar Orbiter Imager (SoloHI) Instrument for the Solar Orbiter Mission
We present the design and pre-launch performance of the Solar Orbiter Heliospheric Imager (SoloHI) which is an instrument prepared for inclusion in the ESA/NASA Solar Orbiter mission, currently scheduled for launch in 2020.
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Estradiol Modulates Recovery of Rem Sleep in a Time-of-Day-Dependent Manner
In this study, we asked whether the effect of ovarian hormones on sleep is mediated via circadian or homeostatic regulatory mechanisms.
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Prolyl Endopeptidase Activity in Bronchoalveolar Lavage Fluid: A Novel Diagnostic Biomarker in a Guinea Pig Model of Invasive Pulmonary Aspergillosis
We are investigating secreted fungal proteases as novel biomarkers for the diagnosis of invasive pulmonary aspergillosis.
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Spectrometer for Sky-Scanning Sun-Tracking Atmospheric Research (4STAR): Instrument Technology
Test results establishing the performance of the instrument against the full range of operational requirements are presented, along with calibration, engineering flight test, and scientific field campaign data and results.
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Privacy in content-oriented networking: threats and countermeasures
In this paper, we present a systematic privacy analysis of CON and the common building blocks among its various architectural instances in order to highlight emerging privacy threats, and analyze a few potential countermeasures.
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Detecting Neurodegenerative Diseases Before Damage Is Done
The brain has amazing capacity to overcome large deficits, which means that by the time a neurodegenerative disease becomes apparent, the damage is extensive. In the case of Parkinson’s disease, for example, more than half of the midbrain region called the substantia nigra can be completely destroyed without any evidence of a problem. But once…
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Development of novel arrayed microjet devices for transdermal drug administration
In this paper we describe a project to leverage this technology to develop novel drug delivery devices for transdermal administration of encapsulated powder vaccines.
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Characterizing user behavior and information propagation on a social multimedia network
Here we discuss our initial analysis of anonymized, scraped data from consenting Facebook users, together with associated demographic and psychological profiles.
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Vacuum steered-electron electric-field sensor
In a new type of MEMS electric-field sensor, a sheet of electrons is thermionically emitted by a hot cathode, flows through a vacuum, and is collected by a pair of anodes 2000 um away.