Author: SRI International
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Lead Optimization of 3-Carboxyl-4(1 H)-Quinolones to Deliver Orally Bioavailable Antimalarials
Herein, we report the lead optimization of 4(1H)-quinolones with a focus on improving both antimalarial potency and bioavailability.
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Thermodynamics and Docking of Agonists to the β 2- Adrenoceptor Determined Using [ 3H](R,R′)-4-Methoxyfenoterol as the Marker Ligand
To better understand the molecular interactions of fenoterol analogs with the β2-adrenergic receptor, we developed a new agonist radioligand for binding assays.
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Design Considerations for Liposomal Vaccines: Influence of Formulation Parameters on Antibody and Cell-Mediated Immune Responses to Liposome Associated Antigens
We present a comprehensive review of the physicochemical properties of liposomal vaccines and how they influence immune responses. A discussion of novel and emerging immunomodulators that are suitable for inclusion in liposomal vaccines is also presented.
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Illinois Preschool for All (PFA) Teacher Characteristics
The PFA evaluation collected information from teachers and administrators about teachers’ demographics, their preparedness to teach, their professional development needs, and their attitudes about their jobs.
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Blurring the boundaries: Understanding disciplinary identities in science education research
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Nicotine Reduces Antipsychotic-Induced Orofacial Dyskinesia in Rats
In this study, we investigated whether nicotine administration could reduce tardive dyskinesia because nicotine attenuates other drug-induced abnormal movements.
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Exploring Design-Based Research in Military Training Environments
The modern military training environment is evolving to meet the needs of soldiers in both current operations and those operations that are expected to arise.
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Ivector-based prosodic system for language identification
In this paper, an automatic language recognition system that extracts prosody information from speech and makes decisions about the language with a generative classifier based on iVectors is built.
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On the Combination of Logical and Probabilistic Models for Information Analysis
We describe a framework for systems that incorporate the advantages of both Bayesian and logical systems. We define a formalism for the conversion of automatically generated natural deduction proof trees into Bayesian networks.
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Synthesis of 14C-Acanthoic Acid
14C-Acanthoic acid was prepared in four steps by a degradation/reconstitution strategy.
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Gene-Centric Analysis of Serum Cotinine Levels in African and European American Populations
We conducted a genetic association study of the biomarker in African American and European American subjects from the Coronary Artery Risk Development in Young Adults study using a chip containing densely-spaced tag SNPs in ~2100 genes.
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The Range of Science Instructional Materials Used in a Statewide Afterschool Program
We report on our study that examined the science offerings of a publicly funded statewide afterschool program.