Author: SRI International
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Nonprofit Organizations and Pharmaceutical Research and Development
To provide a perspective on NPO business models, 10 SRI case studies spanning a broad range of technical and business initiatives are summarized herein, including basic and contract research, discovery of new drugs and biologics, pharmaceutical and biotech R&D services, technology pivots, company spin-ins and spin-outs, and the creation of new NPOs.
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Spin-Orbit Coupling, Spin Relaxation, and Spin Diffusion in Organic Solids
We develop a systematic approach of quantifying spin-orbit coupling (SOC) and a rigorous theory of carrier spin relaxation caused by the SOC in disordered organic solids.
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Competition Between Intradomain and Interdomain Interactions: a Buried Salt Bridge Is Essential for Villin Headpiece Folding and Actin Binding
We used mutational analysis, monitored by CD and NMR, and functional assays to determine the role of this buried salt bridge.
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The First Universal Opioid Ligand, (2S)-2-[(5R,6R,7R,14S)-N- Cyclopropylmethyl-4,5-Epoxy-6,14-Ethano-3-Hydroxy-6-Methoxymorphinan-7-Yl]-3, 3-Dimethylpentan-2-Ol (Bu08028): Characterization of the in Vitro Profile and in Vivo Behavioral Effects in Mouse Models of Acute Pain and Cocaine-Induced Reward
We hypothesized that ligands with buprenorphine’s physical properties, but possessing increased NOP receptor affinity and efficacy, would improve the profile as a drug abuse medication and reduce addiction liability.
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Association of the Calcyon Neuron-Specific Vesicular Protein Gene (Caly) with Adolescent Smoking Initiation in China and California
These results suggest that the CALY gene may influence smoking initiation in adolescents, although the potential roles of underlying psychological characteristics remain to be explored.
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Climatology of Plasma Density Depletions Observed By DMSP in the Dawn Sector
We take advantage of the long history of plasma density measurements by a similar sensor on DMSP spacecraft to determine whether this change is typical of solar minima in general or unique to the present extended quiet time.
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Pontocerebellar Contribution to Postural Instability and Psychomotor Slowing in HIV Infection Without Dementia
We examined whether infratentorial brain tissue volume would be deficient in nondemented HIV-infected individuals and whether selective tissue deficits would be related to postural stability and psychomotor speed performance.
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Disruption of Functional Connectivity of the Default-Mode Network in Alcoholism
We examined DMN functional connectivity using functional magnetic resonance imaging (fMRI) data and graph theory analysis.
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A Melanoma Molecular Disease Model
This paper describes such a Melanoma Molecular Disease Model reflecting the latest scientific, clinical, and technological advances.
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Association of the Nicotine Metabolite Ratio and CHRNA5/CHRNA3 Polymorphisms with Smoking Rate Among Treatment-Seeking Smokers
Genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in the CHRNA5/A3/B4 gene cluster with heaviness of smoking.
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The Effect of Ignoring Classroom-Level Variance in Estimating the Generalizability of School Mean Scores
This paper reports balanced and unbalanced generalizability analyses investigating the consequences of ignoring variation at the level of classrooms within schools when analyzing the reliability of such school-level accountability measures.
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A Collective Intelligence Based Business-Matching and Recommending System for Next Generation E-Marketplaces
The present work proposes and describes a novel approach to business-matching and recommending systems, for the next-generation e-marketplaces, with a focus on the needs and realities of small business.