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Bios September 8, 2021

Thomas Kilduff

Center Director, Center for Neuroscience

Thomas Kilduff, Ph.D., is an expert in the neurobiology of sleep and wakefulness, sleep disorders, and the biological clock. Kilduff was co-first author on the paper that originally described hypocretin/orexin (Hcrt), a neuropeptide system that stimulates arousal and is involved in wakefulness regulation. Dysfunction of the Hcrt system results in narcolepsy, a sleep disorder characterized by excessive daytime sleepiness and a sudden loss of muscle tone known as cataplexy.

In addition to basic research on sleep, his group conducts in vitro and in vivo pharmacology studies related to the development of new medications for the treatment of sleep disorders. Government agencies, private foundations, and pharmaceutical companies have supported this research. Kilduff has authored or co-authored more than 200 published abstracts, scientific articles, and book chapters.

Kilduff was previously a senior research scientist at Stanford University’s Center for Sleep and Circadian Neurobiology. He has been elected to the board of directors of the Sleep Research Society (SRS) and served as secretary/treasurer for both the SRS and SRS Foundation. He received his Ph.D. in biological sciences from Stanford University. In 2010, Kilduff was named a Fellow of the American Association for the Advancement of Science (AAAS).

Kilduff was named an SRI Fellow in 2010 and a Distinguished Scientist by the SRS in 2017.

View Dr. Kilduff’s publications via PubMed or Google Scholar.

Recent publications

more +
Evaluation of the Efficacy of the Hypocretin/orexin Receptor Agonists TAK-925 and ARN-776 in Narcoleptic Orexin/tTA; TetO-DTA Mice  (12/22/2022) - We evaluated the efficacy of two small molecule hypocretin/orexin receptor-2 (HCRTR2) agonists in narcoleptic male orexin/tTA; TetO-DTA mice.
The development of sleep/wake disruption and cataplexy as hypocretin/orexin neurons degenerate in male vs. female Orexin/tTA; TetO-DTA Mice  (12/21/2022) - We compared the development of narcoleptic symptomatology in male vs. female orexin-tTA; TetO-DTA mice, a model in which Hcrt neuron…
Cerebrospinal Fluid Monoamine Levels in Central Disorders of Hypersomnolence (7/9/2021) - Whether the cause of daytime sleepiness in narcolepsy type 1 (NT1) is a direct consequence of the loss of orexin…
Animal Models of Narcolepsy and the Hypocretin/orexin System: Past, Present, and Future (6/11/2021) - Animal models have advanced not only our understanding of the etiology and phenotype of the sleep disorder narcolepsy but have…
Hypocretin/Orexin Receptor Pharmacology and Sleep Phases (5/28/2021) - The involvement of this system in a disorder characterized by the loss of control over arousal state boundaries also suggested…
Dual orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexy (4/21/2020) - Orexin/hypocretin-producing and melanin-concentrating hormone-producing (MCH) neurons are co-extensive in the hypothalamus and project throughout the brain to regulate sleep/wakefulness.

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