Biomedical sciences publications

Bipolar disorder (BPD) and schizophrenia (SCZ) are severe disorders representing an enormous social, familiar and individual burden, being SCZ the most disabling psychiatric disorder characterized by psychosis and cognitive impairment.

Here we analyze the in vivo and in vitro phenotype of mice lacking the GABAB1 gene specifically in orexin neurons (oxGKO mice) and demonstrate that GABAB receptors on orexin neurons are essential in stabilizing and consolidating sleep/wake…

We sought to investigate the NCS-1 expression in lymphocytes and monocytes (CD4+ T lymphocytes, CD56+ NK cells, CD19+ B lymphocytes and CD14+ monocytes) of SCZ and BPD patients.

We used fetal mice and sheep to determine whether PGE2 has a role in the development of ductus contractility that is distinct from its function as a vasodilator.

Here we tested whether nicotine is also beneficial when given to rats and monkeys with pre-existing nigrostriatal damage.

We used quantitative fiber tracking to examine age effects on commissural, bilateral association, and fornix fibers in young and elderly healthy men and women and tested functional correlates with concurrent…

Here we discuss the most commonly used animal models including, self-administration (SA), place conditioning (PC), and the intracranial self-stimulation (ICSS) paradigms in rodents.

Is the annoyance of snoring a reliable tool for the measurement of snoring or does it depend more on the sensitivity of the listener?

The contribution of common genetic variation to one or more established smoking behaviors was investigated in a joint analysis of two genome wide association studies.

This study was designed to determine whether the functional IL-10 gene polymorphism −1082G/A is associated with the development of cardiomyopathy in individuals infected with Trypanosoma cruzi.

P947 improved MR imaging for atherosclerosis through MMP-specific targeting. The results were validated and provide support for further assessment of P947 as a potential tool for the identification of unstable…

A number of studies suggest neuroprotective potential in human neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease.