Biomedical sciences publications
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Expression of Nicotinic Acetylcholine Receptors and Subunit Messenger RNAs in the Enteric Nervous System of the Neonatal Rat
The expression of heteromeric nAChR and receptor subunit mRNAs was investigated in the neonatal rat ENS using receptor autoradiography with the radiolabeled ligand 125I-epibatidine, and in situ hybridization with subtype specific probes for…
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A Consensus Definition of Cataplexy in Mouse Models of Narcolepsy
To establish a common language, the International Working Group on Rodent Models of Narcolepsy reviewed the literature on cataplexy in people with narcolepsy and in dog and mouse models of…
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Enhanced Alpha-Synuclein Expression in Human Neurodegenerative Diseases: Pathogenetic and Therapeutic Implications
Here we discuss the possibility that other mechanisms of alpha-synuclein elevation contribute to the pathogenesis of idiopathic, sporadic Parkinson's disease and other human synucleinopathies.
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Expression of Plasticity-Related Genes During Eszopiclone-Induced Sleep
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Nociceptin/Orphanin FQ Antagonists Ameliorate the Disease Pathogenesis During Inflammatory Bowel Disease
We evaluated the therapeutic potential of N/OFQ antagonists in C57Bl/6 mice in an IBD model after disease induction by treatment for 5 days with DSS, and subsequent observation of the…
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Therapeutic Efficacy of a Melatonin Agonist, Ramelteon, and a Benzodiazepine, Triazolam, in a Mouse Genetic Model of Advanced Sleep Phase Syndrome
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Pharmacokinetics and Immunogenicity Assays for a Human Monoclonal Antibody Mixture Specific for Botulinum Neurotoxin A
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Identification of “Sleep Genes” from Natural and Pharmacologically Induced Sleep Studies
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Processing of Emotional and Alcohol Stimuli in Chronic Alcoholism
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Subject-Matched Templates for Spatial Normalization
Here, we introduce the concept of subject-matched templates. Rather than using a single template for the entire population, a different template is used for every subject, with the template matched…
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The Impact of Alcoholism in Men and Women on Polysomnography and Sleep EEG
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Using Ontologies in Hierarchical Modeling of Genes and Exposure in Biologic Pathways
This chapter examines the potential for the use of hierarchical modeling techniques within the framework of an ontology that quantifies relationships across genotypes and phenotypes for nicotine dependence.