Biomedical sciences publications
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Alpha-Synuclein Suppression By Targeted Small Interfering RNA in the Primate Substantia Nigra
The protein α-synuclein is involved in the pathogenesis of Parkinson’s disease and other neurodegenerative disorders.
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α-Synuclein Suppression By Targeted Small Interfering RNA in the Primate Substantia Nigra
Here, feasibility and safety of α-synuclein suppression were evaluated by treating monkeys with small interfering RNA (siRNA) directed against α-synuclein.
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Association Study of 182 Candidate Genes in Anorexia Nervosa
We performed association studies with 5,151 SNPs that were judged as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN) based on location under reported linkage peaks, previous results…
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3.3: the Development of a Stationary X-Ray Source for Medical Imaging
A prototype stationary source for medical imaging is evaluated. X-ray focal spot diameters of less than 0.2 mm are formed with beam currents of up to 75 mA at beam…
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5′-AMP-Activated Protein Kinase Activity is Elevated Early During Primary Brain Tumor Development in the Rat
We used an established model of brain tumor (glioma) development in the offspring of rats exposed prenatally to the mutagen N-ethyl-N-nitrosourea.
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Improved Oral Bioavailability in Rats of SR13668, A Novel Anti-Cancer Agent
The objective of these studies was to better understand the source of low oral exposure and to develop a formulation that could be used in preclinical development studies.
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Callosal Microstructural Abnormalities in Alzheimer’s Disease and Alcoholism: Same Phenotype, Different Mechanisms
Magnetic resonance and diffusion tensor imaging data were acquired and midsagittal area, length, dorsoventral height, fractional anisotropy, and mean diffusivity of the total corpus callosum and volume of the lateral…
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Genome Sequence of the Necrotrophic Plant Pathogen Pythium Ultimum Reveals Original Pathogenicity Mechanisms and Effector Repertoire
Pythium ultimum is a ubiquitous oomycete plant pathogen responsible for a variety of diseases on a broad range of crop and ornamental species.
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Development and Validation of a High-Throughput Screening Assay for Human Long-Chain Fatty Acid Transport Proteins 4 and 5
The authors used mammalian cell lines stably expressing the recombinant human FATP4 and 5 and developed a high-throughput screening assay using a 96-well fluorometric imaging plate reader.
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Relationship Between Gray Matter Volume and Sleep-Specific Delta Eeg Changes in Alcoholic Men and Women
Our objective is to determine the impact of alcoholism on sleep architecture and sleep EEG power spectra in men and women with uncomplicated alcoholism.
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In Vivo Application of Sub-Second Spiral Chemical Shift Imaging (CSI) to Hyperpolarized 13C Metabolic Imaging: Comparison with Phase-Encoded CSI
A fast spiral chemical shift imaging (CSI) has been developed to address the challenge of the limited acquisition window in hyperpolarized 13C metabolic imaging.
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Volumetric Cerebral Perfusion Imaging in Healthy Adults: Regional Distribution, Laterality, and Repeatability of Pulsed Continuous Arterial Spin Labeling (PCASL)
The regional distribution, laterality, and reliability of volumetric pulsed continuous arterial spin labeling measurements of cerebral blood flow in cortical, subcortical, and cerebellar regions were determined in 10 normal volunteers studied on…