Biomedical sciences publications
-
Expression of Neuronal Calcium Sensor-1 (NCS-1) is Decreased in Leukocytes of Schizophrenia and Bipolar Disorder Patients
We sought to investigate the NCS-1 expression in lymphocytes and monocytes (CD4+ T lymphocytes, CD56+ NK cells, CD19+ B lymphocytes and CD14+ monocytes) of SCZ and BPD patients.
-
Chronic in Utero Cyclooxygenase Inhibition Alters PGE2-Regulated Ductus Arteriosus Contractile Pathways and Prevents Postnatal Closure
We used fetal mice and sheep to determine whether PGE2 has a role in the development of ductus contractility that is distinct from its function as a vasodilator.
-
Pathway Analysis By Adaptive Combination of P-Values
Building upon existing P-value combining methods, we propose a class of highly flexible pathway analysis approaches based on an adaptive rank truncated product statistic that can effectively combine evidence of associations…
-
Thyrotropin-Releasing Hormone Increases Behavioral Arousal Through Modulation of Hypocretin/Orexin Neurons
In vitro electrophysiological studies showed that bath application of TRH caused concentration-dependent membrane depolarization, decreased input resistance, and increased firing rate of identified Hcrt neurons.
-
The Annoyance of Snoring
Is the annoyance of snoring a reliable tool for the measurement of snoring or does it depend more on the sensitivity of the listener?
-
Genome-Wide and Candidate Gene Association Study of Cigarette Smoking Behaviors
The contribution of common genetic variation to one or more established smoking behaviors was investigated in a joint analysis of two genome wide association studies.
-
Functional IL-10 Gene Polymorphism is Associated with Chagas Disease Cardiomyopathy
This study was designed to determine whether the functional IL-10 gene polymorphism −1082G/A is associated with the development of cardiomyopathy in individuals infected with Trypanosoma cruzi.
-
Atherosclerosis and Matrix Metalloproteinases: Experimental Molecular MR Imaging in Vivo
P947 improved MR imaging for atherosclerosis through MMP-specific targeting. The results were validated and provide support for further assessment of P947 as a potential tool for the identification of unstable…
-
Review of the Effects of 17 Alpha-Estradiol in Humans: a Less Feminizing Estrogen with Neuroprotective Potential
A number of studies suggest neuroprotective potential in human neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease.
-
Expression of Nicotinic Acetylcholine Receptors and Subunit Messenger RNAs in the Enteric Nervous System of the Neonatal Rat
The expression of heteromeric nAChR and receptor subunit mRNAs was investigated in the neonatal rat ENS using receptor autoradiography with the radiolabeled ligand 125I-epibatidine, and in situ hybridization with subtype specific probes for…
-
Nicotine Is Neuroprotective When Administered Before But Not After Nigrostriatal Damage in Rats and Monkeys
Here we tested whether nicotine is also beneficial when given to rats and monkeys with pre-existing nigrostriatal damage.
-
Problem Solving, Working Memory, and Motor Correlates of Association and Commissural Fiber Bundles in Normal Aging: a Quantitative Fiber Tracking Study
We used quantitative fiber tracking to examine age effects on commissural, bilateral association, and fornix fibers in young and elderly healthy men and women and tested functional correlates with concurrent…