Biomedical sciences publications
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Children of Persons with Alzheimer Disease: What Does the Future Hold?
Children of persons with Alzheimer disease (AD), as a group, face an increased risk of developing AD.
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Evaluation of Matrix Metalloproteinases in Atherosclerosis Using a Novel Noninvasive Imaging Approach
This study evaluated the ability of the novel gadolinium-based MRI contrast agent P947 to target MMPs in atherosclerotic plaques.
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Roles of Insulin and Transferrin in Neural Progenitor Survival and Proliferation
In the current study, we examined the requirements for NSC proliferation and survival in vitro using the neurosphere culture system.
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Frontal Callosal Fiber Integrity Selectively Predicts Coordinated Psychomotor Performance in Chronic Alcoholism
Quantitative fiber tracking with diffusion tensor imaging (DTI) provides a new approach for assessing deficits in the microstructural integrity of white matter circuits that may underlie cognitive deficits associated with…
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Genes Implicated in Serotonergic and Dopaminergic Functioning Predict BMI Categories
This study addressed the hypothesis that variation in genes associated with dopamine function, serotonin function (SLC6A4, and regulation of monoamine levels (MAOA) may be predictive of BMI categories in young…
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Genetic and Environmental Influences on Nicotine Pharmacokinetic and Pharmacodynamic Phenotypes
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A Mouse Model for Familial Advanced Sleep Phase Syndrome
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Low Striatal Glutamate Levels Underlie Cognitive Decline in the Elderly: Evidence from in Vivo Molecular Spectroscopy
Here, we used a spectroscopic protocol, optimized for Glu detection, to examine the effect of age in 3 brain regions targeted by cortical efferents—the striatum, cerebellum, and pons—and to test…
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Who is to Blame if Snoring Becomes a Problem?
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Identification of Novel Cyp2A6*1B Variants: the Cyp2A6*1B Allele Is Associated with Faster in Vivo Nicotine Metabolism
We report evidence that CYP2A6*1B genotype is associated with faster nicotine clearance in vivo, which will be important to future CYP2A6 genotype association studies.
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Respiratory-Related Evoked Potentials During Sleep in Children
There have been no data on RREP during sleep in children. We thus examined children during sleep to determine whether early RREP components would be maintained during all sleep.
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AMP-Activated Protein Kinase Inhibits Transforming Growth Factor-Beta-Induced Smad3-Dependent Transcription and Myofibroblast Transdifferentiation
In wound healing, myofibroblast transdifferentiation (MFT) is a metaplastic change in phenotype producing profibrotic effector cells that secrete and remodel the extracellular matrix.