SRI International
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H1N1 infection of sleep/wake regions results in narcolepsy-like symptoms
The neurological basis for narcolepsy resides in the degeneration of the hypothalamic neurons that produce the neuropeptide hypocretin, but how and why these specific cells die is one of the most important, unanswered questions in the field.
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AC3N: Anonymous communication in Content-Centric Networking
Abstract Content-Centric Networking (CCN) is an emerging (inter-)networking architecture with the goal of becoming an alternative to the IP-based Internet. To be considered a vi- able candidate, CCN must at least have parity with existing solutions for confidential and anonymous communication, e.g., TLS, tcpcrypt, and Tor. ANDa NA (Anonymous Named Data Networking Application) was the…
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Handbook on Personalized Learning for States, Districts, and Schools
Chapters in this new Handbook reflect the personalized learning goals of ESSA and reflect the view of personalized learning as a learning innovation.
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Fragment-based screening for enzyme inhibitors using calorimetry
This article describes how nanocalorimetry and conventional microcalorimetry can be used to screen compound libraries for enzyme inhibitors.
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Crowd-sourcing and author submission as alternatives to professional curation
This perspective considers the significant experience accumulated by the bioinformatics community with these two alternatives to professional curation in the last 20 years…
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How the strengths of Lisp-family languages facilitate building complex and flexible bioinformatics applications
We present a rationale for expanding the presence of the Lisp family of programming languages in bioinformatics and computational biology research.
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Representation and inference of cellular architecture for metabolic reconstruction and modeling
We developed a tool for inferring cellular architectures across many domains of life and extended our Cell Component Ontology to enable representation of the inferred architectures.
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Can we replace curation with information extraction software?
Can we use programs for automated or semi-automated information extraction from scientific texts as practical alternatives to professional curation? I show that error rates of current information extraction programs are too high to replace professional curation today.
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Examining Change in K-3 Teachers’ Mathematical Knowledge, Attitudes, and Beliefs: The Case of Primarily Math
This study examines the impact of the Primarily Math Elementary Mathematics Specialist program on K-3 teachers’ mathematical content knowledge for teaching, attitudes toward learning mathematics, and beliefs about mathematics teaching and learning.
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Assessing Problem-Solving Process At Scale
This paper describes a hybrid approach to assessing process at scale in the context of the use of computational thinking practices during programming.
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Pathway collages: personalized multi-pathway diagrams
We define software for constructing personalized multi-pathway diagrams called pathway-collages using a combination of manual and automatic layouts.
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An Annotated Corpus and Method for Analysis of Ad-Hoc Structures Embedded in Text
We describe a method for identifying and performing functional analysis of structured regions that are embedded in natural language documents, such as tables or key-value lists.