SRI International
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NMR Characterization of an Oligonucleotide Model of the MiR-21 Pre-Element
We have used NMR spectroscopy to characterize an oligonucleotide stem loop structure based on the pre-element of an oncogenic microRNA, miR-21.
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Representing Roles in a Biology Textbook
In this paper, we consider the roles in a biology textbook, adapt a definition of roles based on upper ontologies, and relate it to the corresponding notions in linguistics and description logics. We consider our solutions to several conceptual modeling problems for roles as we have used them in representing the knowledge contained in a…
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Mining Structure Fragments for Smart Bundle Adjustment
In this work we show that, when using conjugate gradient solvers, there is a computational advantage in “grouping” factors corresponding to sets of points (fragments) that are co-visible by the same set of cameras.
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Strategies towards Compact UV Laser Sources
There is increasing interest in developing compact UV laser sources that emit at wavelengths below 300 nm.
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Building Community & Commitment with a Virtual Coach in Mobile Wellness Programs
Here we present a quantitative analysis from a 2-week field study where we test new FittleBot strategies to increase FittleBots effectiveness in building team community.
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Crowdsourcing Program Tests Combined Opinions of Scientists and Technology Enthusiasts to Predict Scientific and Technological Events
Researchers are looking at crowdsourcing to gain a better view into future significant scientific and technological developments, particularly in areas such as information systems and energy where corporations may want to focus development efforts and investments. Crowdsourcing often provides more accurate forecasts by aggregating the collective opinions of an informed, diverse group rather than relying…
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Best Practices for Recruiting Schools for Educational Studies
In a recent report, “Recruiting Participants for Large-Scale Random Assignment Experiments in School Settings,” a team of SRI Education researchers share practical advice on how to recruit schools for educational studies. There is an art to successful recruitment, but there are few occasions for experienced researchers to share lessons learned about recruitment with colleagues. The report synthesizes the SRI…
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Deep Knowledge and the Rise of Virtual Specialists
Virtual personal assistants like Siri are becoming widespread. They understand user intents expressed in natural language and respond by connecting users with services that hopefully fulfill those intents. But for many consumer needs such as banking, retail, and healthcare, just getting to the service isn’t enough. Consumers have difficulty getting things done in the service, especially when…
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A Multiparameter Aerosol Classification Method and Its Application to Retrievals from Spaceborne Polarimetry
Classifying observed aerosols into types helps to understand aerosol sources, transformations, effects, and feedback mechanisms; to improve accuracy of satellite retrievals; and to quantify aerosol radiative impacts on climate.
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Cortical nNOS/NK1 Neurons Are Regulated by Cholinergic Inputs
CCh has a network effect on excitability within the cortex, as both presynaptic and postsynaptic effects result in an oscillating pattern of nNOS/NK1 neuron excitability.
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Synthesis of Doxycycline-[(CD3)-C-13]
In this process, doxcycline was oxidized to the N-oxide using m-CPBA. The hydrochloride salt of the tertiary N-oxide was treated with Fe(0)/FeCl3 catalyst yielding the N-demethylated product.
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White Matter Microstructural Recovery with Abstinence and Decline with Relapse in Alcohol Dependence Interacts with Normal Ageing: A Controlled Longitudinal DTI Study
Background Alcohol dependence exacts a toll on brain white matter microstructure, which has the potential of repair with prolonged sobriety. Diffusion tensor imaging (DTI) enables in-vivo quantification of tissue constituents and localisation of tracts potentially affected in alcohol dependence and its recovery. We did an extended longitudinal study of alcoholism’s trajectory of effect on selective…