SRI International
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Cyanide Detoxification by Molybdenum Sulfur Complexes
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Characterization of Genetic Variation in the Vgll4 Gene in Anorexia Nervosa
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A Multiparameter Aerosol Classification Method and Its Application to Retrievals from Spaceborne Polarimetry
Classifying observed aerosols into types helps to understand aerosol sources, transformations, effects, and feedback mechanisms; to improve accuracy of satellite retrievals; and to quantify aerosol radiative impacts on climate.
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Cortical nNOS/NK1 Neurons Are Regulated by Cholinergic Inputs
CCh has a network effect on excitability within the cortex, as both presynaptic and postsynaptic effects result in an oscillating pattern of nNOS/NK1 neuron excitability.
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Synthesis of Doxycycline-[(CD3)-C-13]
In this process, doxcycline was oxidized to the N-oxide using m-CPBA. The hydrochloride salt of the tertiary N-oxide was treated with Fe(0)/FeCl3 catalyst yielding the N-demethylated product.
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Recruiting Participants for Large-Scale Random Assignment Experiments in School Settings
We report here on our experiences in recruiting participants for random assignment experiments in public primary and secondary schools. Our perspective is based on over twenty current and completed randomized controlled trials (RCT) in K–12 school settings conducted by SRI International.
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White Matter Microstructural Recovery with Abstinence and Decline with Relapse in Alcohol Dependence Interacts with Normal Ageing: A Controlled Longitudinal DTI Study
Background Alcohol dependence exacts a toll on brain white matter microstructure, which has the potential of repair with prolonged sobriety. Diffusion tensor imaging (DTI) enables in-vivo quantification of tissue constituents and localisation of tracts potentially affected in alcohol dependence and its recovery. We did an extended longitudinal study of alcoholism’s trajectory of effect on selective…
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PreK– 3 Family Engagement and Literacy
The McKnight Foundation’s Education and Learning (E&L) Program is promoting family engagement as part of a literacy initiative that spans from prekindergarten through third grade (PreK–3).
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Building a Breathprint: Biomarkers of Exposure Due to the Toxicant Trochloroethylene
Our pilot studies indicate that we can detect TCE and other VOCs in the breath environment that are indicative of neuronal degeneration. Pending studies will investigate the relationship between toxicant exposure and VOCs with known markers of nigrostriatal damage in animal models which can be correlated to VOCs from breath samples of human PD patients.
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Development of an Agonist of the TGF-Beta Signaling Pathway to Treat Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder that leads to progressive cognitive dysfunction. Current knowledge of the processes leading to AD is still limited, and no effective treatments are available. Because neurodegeneration is associated with injury and activation of innate immune responses in the brain, drugs that could mimic the beneficial aspects of this response…
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PreK– 3 Teacher Instructional Practices
A key component of the McKnight Foundation’s Education and Learning (E&L) Program is supporting PreK–3 teachers to improve their literacy instruction in order to develop proficient readers.
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Research Brief: Implementation of the New Educator Evaluation System in Massachusetts
During the 2013-14 school year, the second year of the study, the research team conducted educator interviews and focus groups in 12 Massachusetts case study districts.