SRI International
-
Dynamic Metabolic Imaging of Hyperpolarized [2-C-13]Pyruvate Using Spiral Chemical Shift Imaging with Alternating Spectral Band Excitation
This study introduces a sequence for three-dimensional CSI of [2-(13) C]pyruvate using spectrally selective excitation of limited frequency bands containing a subset of metabolites. Dynamic CSI data were acquired alternately from multiple frequency bands in phantoms for sequence testing and in vivo in rat heart.
-
A Genome-Scale Metabolic Flux Model of Escherichia coli K-12 Derived from the EcoCyc Database
We present EcoCyc–18.0–GEM, a genome-scale model of the E. coli K–12 MG1655 metabolic network.
-
Evidence for the Role of EPHX Gene Variants in Anorexia Nervosa
To identify genetic variants associated with AN, we pursued a series of sequencing and genotyping studies focusing on the coding regions and upstream sequence of 152 candidate genes in a total of 1205 AN cases and 1948 controls.
-
Implementation of an Intelligent Tutoring System for Online Homework Support in an Efficacy Trial
In this paper, we describe an ongoing randomized controlled trial (RCT) to evaluate the efficacy of a web-based tutoring system—the ASSISTments—as support for homework.
-
The CHERI Capability Model: Revisiting RISC in an Age of Risk
Motivated by contemporary security challenges, we reevaluate and refine capability-based addressing for the RISC era. We present CHERI, a hybrid capability model that extends the 64-bit MIPS ISA with byte-granularity memory protection.
-
Trajectory of Visuospatial Learning Compromise in Alcoholism with and without HIV Infection: 10-Year Longitudinal Study
-
A Design Inquiry: Bridging Assessment and Curriculum Frameworks to Engage Students in Science Practices
This reflective inquiry delves into the collaborative design process of a technology based middle school genetics unit. With a lens on science practices, we describe how bridging assessment and curriculum design frameworks can inform decisions in an iterative co-design process.
-
In Vivo Diffusion Tensor Imaging Evidence for Reversible White Matter Microstructural Integrity Disruption: Effects of Abstinence in Rat and Man
-
Sleep EEG Evidence of Early Brain Recovery with Abstinence in Long-Term Alcoholics
-
Design and Synthesis of Molecular Probes for the Determination of the Target of the Anthelmintic Drug Praziquantel
In this Letter, we report an efficient protocol for the small-scale separation of enantiomers of 2 (hydrolyzed PZQ) using supercritical fluid chromatography (SFC).
-
Evidence of Recovery in Cortico-Cardiac Activity During Sleep in Recently Detoxified Alcoholics
-
Implementation Science in School Mental Health: Key Constructs in a Developing Research Agenda
In this paper, we propose an implementation science research agenda as it applies to school mental health (SMH).