SRI International
-
Pharmacological Inhibition of Glucocerebrosidase Disrupts Striatal Dopaminergic Neurotransmission
To deconstruct the biochemical correlates involved in this association, we evaluated striatal dopaminergic function in a pharmacological model of Gaucher disease using the selective irreversible inhibitor of glucocerebrosidase, conduritol B epoxide (CBE).
-
High Frequency Neuronal Oscillations in a Cynomologus Macaque Test of Sustained Attention Following Nmda Receptor Antagonism
These studies may help to define the role of high frequency oscillations in cognitive processes in higher order species, and to enhance our understanding of EEG recordings as a translatable biomarker for CIAS.
-
Hyperspectral Aerosol Optical Depths from TCAP Flights
The favorable intercomparisons herald 4STAR’s spatially-resolved high-frequency hyperspectral products as a reliable tool for climate studies and satellite validation.
-
Neural Correlates of Cognitive Interference and Response Switching in Mild Parkinson Disease
-
Field Ionization Characteristics of an Ion Source Array for Neutron Generators
Ion currents from single etched-wire tips operating under the same conditions are used to help understand array results. I-F characteristics of the arrays were found to follow trends similar to those of the better understood single etched-wire tip results; however, the fields achieved by the arrays are limited by electrical breakdown of the structure.
-
Formulation Development of Acyclovir/Tenofovir Loaded Two-Polymer (SR-2P) Bioadhesive Vaginal Gel
The in vitro release of drugs from the optimized gel formulation in simulated vaginal fluid was characterized using in-line Franz diffusion cell with regenerated cellulose membrane.
-
Long-Term Ethanol Consumption Changes the Expression of Neuronal Nicotinic Receptors – Implications for Treatment Strategies
-
AT-202, a Nociceptin Receptor Agonist, Blocks Drug- and Stress-Induced Reinstatement of Extinguished Cocaine Conditioned Place Preference
In the present study we examined the effects of AT-202 on acquisition and drug-primed or stress-induced reinstatement of cocaine CPP. These findings provide preliminary evidence that the NOP receptor agonists may be useful as pharmacotherapies to treat psychostimulant addiction and may be especially valuable in relapse prevention.
-
Diffustion Tensor Imaging Detects Callosal Fiber Integrity Change over a 1-Year Follow-up in Chronic Alcoholics Who Maintained Sobriety
Here, we investigated change in CC microstructural fiber integrity over one year in 12 (7w, 5m) alcoholics (ALC) and 13 (7w, 6m) age-matched controls (CTL). ALC and CTL did not differ in years of education (mean=15 years for both groups) or verbal IQ (CTL=107, ALC=104).
-
Forward Acceleration of Ionospheric Electrons by Nau 40.75-KHz Whistler Waves over Arecibo
We discuss a new mechanism to explain the forward acceleration of ionospheric electrons by whistler waves.
-
Aberrant Heat Shock Protein Response Is Accompanied by Oxidative Injury in Aged DJ-1 Deficient Mice
Loss of DJ-1 function contributes to pathogenesis in Parkinson’s disease. Here, we investigate the impact of aging and DJ-1 deficiency in mice.
-
Varenicline Markedly Decreases Antipsychotic-Induced Tardive Dyskinesia in a Rodent Model
Tardive dyskinesia is a potentially irreversible drug-induced movement disorder that arises as a side effect of antipsychotic therapy. Antipsychotics form the mainstay of treatment for schizophrenia and bipolar disorder and, in addition, are increasingly being prescribed for major depressive disorder, autism, attention deficit hyperactivity disorder, obsessive compulsive disorder and post-traumatic stress disorder. There is therefore…