SRI International
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Optogenetic Silencing of Hypocretin/Orexin Neurons Using Transgenic Expression of a Light-Driven Proton Pump
Arch may be better suited for long-term circuit inhibition, and may serve as an important tool for deciphering the role of Hcrt signaling in the maintenance of wakefulness.
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Pharmacological Inhibition of Glucocerebrosidase Disrupts Striatal Dopaminergic Neurotransmission
To deconstruct the biochemical correlates involved in this association, we evaluated striatal dopaminergic function in a pharmacological model of Gaucher disease using the selective irreversible inhibitor of glucocerebrosidase, conduritol B epoxide (CBE).
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High Frequency Neuronal Oscillations in a Cynomologus Macaque Test of Sustained Attention Following Nmda Receptor Antagonism
These studies may help to define the role of high frequency oscillations in cognitive processes in higher order species, and to enhance our understanding of EEG recordings as a translatable biomarker for CIAS.
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Hyperspectral Aerosol Optical Depths from TCAP Flights
The favorable intercomparisons herald 4STAR’s spatially-resolved high-frequency hyperspectral products as a reliable tool for climate studies and satellite validation.
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Neural Correlates of Cognitive Interference and Response Switching in Mild Parkinson Disease
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AT-202, a Nociceptin Receptor Agonist, Blocks Drug- and Stress-Induced Reinstatement of Extinguished Cocaine Conditioned Place Preference
In the present study we examined the effects of AT-202 on acquisition and drug-primed or stress-induced reinstatement of cocaine CPP. These findings provide preliminary evidence that the NOP receptor agonists may be useful as pharmacotherapies to treat psychostimulant addiction and may be especially valuable in relapse prevention.
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Field Ionization Characteristics of an Ion Source Array for Neutron Generators
Ion currents from single etched-wire tips operating under the same conditions are used to help understand array results. I-F characteristics of the arrays were found to follow trends similar to those of the better understood single etched-wire tip results; however, the fields achieved by the arrays are limited by electrical breakdown of the structure.
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Formulation Development of Acyclovir/Tenofovir Loaded Two-Polymer (SR-2P) Bioadhesive Vaginal Gel
The in vitro release of drugs from the optimized gel formulation in simulated vaginal fluid was characterized using in-line Franz diffusion cell with regenerated cellulose membrane.
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Long-Term Ethanol Consumption Changes the Expression of Neuronal Nicotinic Receptors – Implications for Treatment Strategies
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Reaching Populations Faster in Emergency Management of Disasters – Oral Drugs as Antidotes to Radiation Exposure
Without warning, a major earthquake and subsequent tsunami hit Japan in March 2011. Damage was significant at almost every level, impacting people and the environment. Shortly thereafter, a core meltdown at the Fukushima Daiichi nuclear plant—the largest nuclear event since the Chernobyl disaster in 1986—intensified the situation. Almost immediately concern arose about the many health…
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Invasion biology and the success of social collaboration networks, with application to Wikipedia
We adapt methods from the stochastic theory of invasions for which a key question is whether a propagule will grow to an established population or fail to show how monitoring early participation in a social collaboration network allows prediction of success.
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Miniaturized opto-fluidic system for on-the-flow analyte characterization based on spatial modulation technique
A compact opto-fluidic detection platform for on-the-flow analyte characterization is described.