SRI International
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Gender-Stratified Gene and Gene-Treatment Interactions in Smoking Cessation
We conducted gender-stratified analyses on a systems-based candidate gene study of regions involved in nicotinic response and the brain—reward pathway in two randomized clinical trials of smoking cessation treatments (placebo, bupropion, transdermal and nasal spray nicotine replacement therapy).
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Replaying the Fracture Process of a Failed Space Shuttle Orbiter Thruster
The work shows how a failure event can be replayed through fracture surface topography analysis, FRASTA, and how information on load conditions, relative crack growth rates, and fracture mechanics parameters may be extracted from fracture surfaces.
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Two-dimensional deformation potential model of mobility in small molecule organic semiconductors: DNTT-C10 and BTBT-C12
The high mobility measured in alkylated DNTT and BTBT molecules [1,2] raises the possibility that band transport may be achievable in solution processed organic semiconductors.
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Handheld flow cytometer for rapid pathogen characterization in water
In order to achieve more timely assessment of water quality, PARC is developing a compact and robust platform for rapid pathogen characterization in water.
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Finding the Links between College-Level STEM Participation and Autism Spectrum Disorder
There’s a common perception that people with Autism Spectrum Disorders (ASDs) are more likely than the general population to gravitate toward science, technology, engineering, and mathematics (STEM) fields. It turns out the perception is true. Our study results, published online in the November 1 issue of Journal of Autism and Developmental Disorders, confirmed for the first…
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Closing the Gap between Science Students and STEM Workers of the Future
Many of today’s high-wage jobs and fastest growing occupations require science, technology, engineering, and math (STEM) skills. There is general agreement that strengthening STEM teaching and learning is key to workforce readiness and growth of the U.S. economy. Tomorrow’s thinkers will need STEM skills to develop innovative solutions to the world’s increasingly complex problems. Yet,…
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Reframing the Debate about the Future of Our Energy Supply
Today is Election Day—and no matter who wins, our energy problems will continue to be a prominent but unfortunately neglected issue. To date, the political debate has been oversimplified and presented as a battle between the moral imperatives of protecting the environment and the critical need to preserve our economic interests. Too often, our difficult…
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Privacy Preserving Data Quality Assessment
This paper examines challenges in privacy-preserving data quality assessment.
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An analysis of how ensembles of collective classifiers improve predictions in graphs
In this paper, we present a theoretical analysis framework that shows how ensembles of collective classifiers can improve predictions for graph data.
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EcoCyc: Fusing Model Organism Databases with Systems Biology
Updates to EcoCyc content continue to improve the comprehensive picture of E. coli biology. The utility of EcoCyc is enhanced by new tools available on the EcoCyc web site, and the development of EcoCyc as a teaching tool is increasing the impact of the knowledge collected in EcoCyc.
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Discovery and Pharmacological Evaluation of a Diphenethylamine Derivative (HS665), a Highly Potent and Selective Kappa Opioid Receptor Agonist
Here we report on the design, synthesis, and biological characterization of novel κ opioid (KOP) receptor ligands of diphenethylamines.
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Experimental Investigation of Hydrogen Release and Ignition from Fuel Cell Powered Forklifts in Enclosed Spaces
Conducted experiments were devised to assess the utility of modeling approaches used to analyze potential consequences from ignited hydrogen leaks in facilities certified according to existing code language.