SRI International
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Evaluating the usability of a professional modeling tool repurposed for middle school learning
This paper reports the results of a three-stage usability test of a modeling tool designed to support learners’ deep understanding of the impacts of climate change on ecosystems.
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Current Understanding of Immunity to Trypanosoma Cruzi Infection and Pathogenesis of Chagas Disease
The pathogenesis of Chagas disease is complex and multifactorial involving many interactive pathways. The significance of innate immunity, including the contributions of cytokines, chemokines, reactive oxygen species, and oxidative stress, has been emphasized.
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Vector Competence of Aedes Albopictus from Virginia and Georgia for Chikungunya Virus Isolated in the Comoros Islands
We evaluated recently colonized samples from Virginia and Georgia (USA) of Aedes albopictus, an important vector of chikungunya virus to determine whether they became infected with and transmitted COM125, a CHIKV isolate from the Comoros Islands.
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Efficacy of the GluK1/AMPA Receptor Antagonist LY293558 Against Seizures and Neuropathology in a Soman-Exposure Model without Pretreatment and its Pharmacokinetics After Intramuscular Administration
To determine if control of seizures and survival are still possible without pretreatment or immediate pharmacologic intervention, we studied the anticonvulsant efficacy of the GluK1 receptor antagonist.
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Evaluation of the California Linked Learning District Initiative Third-year report
This report presents preliminary findings on student outcomes and the status of implementation of the initiative in its third year.
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Differential Contribution of Lipoxygenase Isozymes to Nigrostriatal Vulnerability
To determine whether the isozymes contribute differently to nigrostriatal vulnerability, the effects of 5- and 12/15-LOX deficiency on dopaminergic tone under naïve and toxicant-challenged conditions were tested.
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Evaluation of the California Linked Learning District Initiative. Third-year report executive summary.
SRI is conducting a rigorous evaluation of Linked Learning in a set of California school districts. Early findings indicate that participating students are: on track for high school graduation; preparing for college; and building skills for career and life. This document summarizes these and other findings drawn from a full report covering the first three…
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Detection of scene obstructions and persistent view changes in transportation camera systems
Since these systems are often unattended, it is often important to automatically detect such incidents early. In this paper, we describe innovative algorithms to address these problems.
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Reference image-independent fault detection in transportation camera systems for nighttime scenes
To address this, we present image quality metrics that can be extracted without a nominal reference image and can be used to characterize these problems.
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EsPRESSo: efficient privacy-preserving evaluation of sample set similarity
This paper presents the first efficient and provably-secure construction for privacy-preserving evaluation of sample set similarity, measured as the Jaccard similarity index.
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Flexible large-area electronics made by additive printing
The vision for additive printing of flexible electronics is on-demand digital fabrication/integration of electronics on any surface.
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The Role of Nonprofit Institutes in Pharmaceutical Development
When I describe to friends and colleagues what I do for a living, I typically get a response like, “So, you are really no different than a pharmaceutical company.” Exactly. And not at all. SRI International has played a major role in the development of therapeutics for a wide range of diseases over the years…