Author: SRI International
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The Growth Factor Progranulin Binds to Tnf Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice
We report that PGRN bound directly to tumor necrosis factor receptors (TNFRs) and disturbed the TNFα-TNFR interaction. PGRN-deficient mice were susceptible to collagen-induced arthritis, and administration of PGRN reversed inflammatory arthritis.
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Using Large-Scale Databases in Evaluation: Advances, Opportunities, and Challenges
The authors illustrate both the opportunities provided by higher quality, interoperable data systems and the challenges encountered when using databases to identify issues of concern, test the plausibility of a proposed theory of action, or evaluate an existing program.
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Sensitivity to Secondhand Smoke Exposure Predicts Smoking Susceptibility in 8-13-Year-Old Never Smokers
We assessed the sensitivity to SHSe using reactions commonly used for the assessment of sensitivity to the first-smoked cigarette, and investigated the factor structure of these reactions for the purpose of data reduction.
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Thermal and Electrical Transport Properties of Spark Plasma-Sintered HfB2 and ZrB2 Ceramics
The thermal conductivity was found to decrease with increasing temperature for all materials. Results are discussed in terms of sample morphology and compared with data previously reported in the scientific literature.
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Summer Blooms of Diatom-Diazotroph Assemblages and Surface Chlorophyll in the North Pacific Gyre: a Disconnect
We compared diatom-diazotroph assemblage abundance to size-fractionated chlorophyll and satellite ocean color chlorophyll estimates to evaluate how DDAs affected ocean color estimates in the eastern and central North Pacific gyre at 28–30°N.
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Spin-Orbit Coupling, Spin Relaxation, and Spin Diffusion in Organic Solids
We develop a systematic approach of quantifying spin-orbit coupling (SOC) and a rigorous theory of carrier spin relaxation caused by the SOC in disordered organic solids.
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Competition Between Intradomain and Interdomain Interactions: a Buried Salt Bridge Is Essential for Villin Headpiece Folding and Actin Binding
We used mutational analysis, monitored by CD and NMR, and functional assays to determine the role of this buried salt bridge.
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Nonprofit Organizations and Pharmaceutical Research and Development
To provide a perspective on NPO business models, 10 SRI case studies spanning a broad range of technical and business initiatives are summarized herein, including basic and contract research, discovery of new drugs and biologics, pharmaceutical and biotech R&D services, technology pivots, company spin-ins and spin-outs, and the creation of new NPOs.
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The First Universal Opioid Ligand, (2S)-2-[(5R,6R,7R,14S)-N- Cyclopropylmethyl-4,5-Epoxy-6,14-Ethano-3-Hydroxy-6-Methoxymorphinan-7-Yl]-3, 3-Dimethylpentan-2-Ol (Bu08028): Characterization of the in Vitro Profile and in Vivo Behavioral Effects in Mouse Models of Acute Pain and Cocaine-Induced Reward
We hypothesized that ligands with buprenorphine’s physical properties, but possessing increased NOP receptor affinity and efficacy, would improve the profile as a drug abuse medication and reduce addiction liability.
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Association of the Calcyon Neuron-Specific Vesicular Protein Gene (Caly) with Adolescent Smoking Initiation in China and California
These results suggest that the CALY gene may influence smoking initiation in adolescents, although the potential roles of underlying psychological characteristics remain to be explored.
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Climatology of Plasma Density Depletions Observed By DMSP in the Dawn Sector
We take advantage of the long history of plasma density measurements by a similar sensor on DMSP spacecraft to determine whether this change is typical of solar minima in general or unique to the present extended quiet time.
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Influence of series resistance on the photocurrent analysis of organic solar cells
A model for the effect is described and shows that P(V) can be significantly modified, particularly at high bias voltages.