Author: SRI International
-
Detoxification of Molinate Sulfoxide: Comparison of Spontaneous and Enzmatic Glutathione Conjugation Using Human and Rat Liver Cytosol
This study compared the metabolic capability of rat and human liver cytosol to form a glutathione (GSH)-conjugated metabolite of molinate.
-
In Vivo Evidence for Alcohol-Induced Neurochemical Changes in Rat Brain Without Protracted Withdrawal, Pronounced Thiamine Deficiency, or Severe Liver Damage
Longitudinal effects of alcohol on brain metabolites measured in basal ganglia with single-voxel MRS were investigated in sibling pairs of wild-type Wistar rats, with one rat per pair exposed to escalating doses of vaporized alcohol, the other to vapor chamber air.
-
Learning diagnostic models using speech and language measures
We describe results that show the effectiveness of machine learning in the automatic diagnosis of certain neurodegenerative diseases, several of which alter speech and language production. We analyzed audio from 9 control subjects and 30 patients diagnosed with one of three subtypes of Frontotemporal Lobar Degeneration.
-
Genetic Influences in the Variation in Renal Clearance of Nicotine and Cotinine
In this study of 139 pairs of twins, we have estimated the genetic and environmental contributions to total renal clearance and net secretory/ reabsorptive clearance of nicotine and cotinine.
-
Adamantyl-Substituted Retinoid-Derived Molecules That Interact with the Orphan Nuclear Receptor Small Heterodimer Partner: Effects of Replacing the 1-Adamantyl or Hydroxyl Groupon Inhibition of Cancer Cell Growth, Induction of Cancer Cell Apoptosis, and Inhibition of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-2 Activity
Abstract (E)-4-[3-(1-Adamantyl)-4′-hydroxyphenyl]-3-chlorocinnamic acid (3-Cl-AHPC) induces the cell-cycle arrest and apoptosis of leukemia and cancer cells. Studies demonstrated that 3-Cl-AHPC bound to the atypical orphan nuclear receptor small heterodimer partner (SHP). Although missing a DNA-binding domain, SHP heterodimerizes with the ligand-binding domains of other nuclear receptors to repress their abilities to induce or inhibit gene expression.…
-
Noninteractive Statistical Zero-Knowledge Proofs for Lattice Problems
We construct noninteractive statistical zero-knowledge (NISZK) proof systems for a variety of standard approximation problems on lattices, such as the shortest independent vectors problem and the complement of the shortest vector problem.
-
The Assistment Builder: Supporting The Life-Cycle Of ITS Content Creation
We present an authoring tool designed to reduce this cost. The ASSISTment Builder is a tool that is designed to effectively create, edit, test, and deploy pseudo-tutor content. The web-based interface simplifies the process of tutor construction to allow users with little or no programming experience to develop content.
-
Comparing Two Strains of Rats in the Chronic Construction Injury Model of Neuropathic Pain
-
Ground-Level Nitrogen Dioxide Concentrations Inferred from the Satellite-Borne Ozone Monitoring Instrument
We present an approach to infer ground-level NO2 concentrations by applying local scaling factors from a global three-dimensional model to tropospheric NO2 columns retrieved from the Ozone Monitoring Instrument onboard the Aura satellite.
-
How Do We Certify for the Unexpected?
We propose that safety cases based on explicit goals, evidence, and argument provide a firmer foundation for assurance, and a framework within which it is possible to address the rare and the unexpected. Specifically, we propose that just as methods to prevent loss of control move certain software adaptation processes to runtime, so should some…
-
Improving alignments for better confusion networks for combining machine translation systems
The state-of-the-art system combination method for machine translation (MT) is the word-based combination using confusion networks. One of the crucial steps in confusion network decoding is the alignment of different hypotheses to each other when building a network. In this paper, we present new methods to improve alignment of hypotheses using word synonyms and a…
-
Microfabricated Field Emitter Arrays for Electron and Ion Emission