Author: Thomas Kilduff
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Microinjections of the Hypocretin Antagonist Almorexant Vs. Gabaergic Agonist Zolpidem in Basal Forebrain Show Differential Effects on Cortical Adenosine Levels in Freely-Moving Rats
We used in vivo microdialysis and HPLC analysis to examine cortical adenosine (ADO) levels following BF microinjections of ZOL (0.6 µg/0.2 µl), ALM (1.0 µg/0.2 µl), or VEH (aCSF) combined with behavioral analyses. Preliminary analyses revealed a significant main effect of drug on ADO levels.
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Influence of Inhibitory Serotonergic Inputs to Orexin/Hypocretin Neurons on the Diurnal Rhythm of Sleep and Wakefulness
Inhibitory serotonergic input likely contributes to wakefulness bouts, affecting the diurnal rhythm of sleep and wakefulness.
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On the Potential to Enhance the Spatial Resolution of the Day/Night Band (DNB) Channel of the Visible and Infrared Imaging Radiometer Suite (VIRRS) for the Second Joint Polar Satellite System (JPSS-2) and Beyond
This paper examines the feasibility and potential benefits of enhancing the spatial resolution of the VIIRS DNB channel for the JPSS-2 mission and beyond.
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Animal Care Practices in Experiments on Biological Rhythms and Sleep: Report of the Joint Task Force of the Society for Research on Biological Rhythms and the Sleep Research Society
This report reviews requirements for experiments on biological rhythms and sleep and discusses how scientific considerations can be reconciled with the recommendations of the Guide.
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Longitudinal Analysis of the Electroencephalogram and Sleep Phenotype in the R6/2 Mouse Model of Huntington’s Disease
We conducted a longitudinal characterization of sleep/wake and electroencephalographic activity in the R6/2 mouse model of Huntington’s disease to determine whether analogous electroencephalographic ‘signatures’ could be identified early in disease progression.
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A New Perspective for Schizophrenia: TAAR1 Agonists Reveal Antipsychotic- and Antidepressant-Like Activity, Improve Cognition and Control Body Weight
We show that activation of the trace amine-associated receptor 1 (TAAR1), a modulator of monoaminergic neurotransmission, represents a novel therapeutic option.
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Almorexant Promotes Sleep and Exacerbates Cataplexy in a Murine Model of Narcolepsy
The current study was designed to evaluate the hypnotic and cataplexy-inducing efficacy of a Hcrt antagonist in an animal model with low Hcrt tone and compare the ALM efficacy profile in the disease model to that produced in wild-type (WT) control animals.
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Understanding the Sleep-Wake Cycle: Sleep, Insomnia, and the Orexin System
Andrew D. Krystal, MD, MS, gathered a panel of experts in the area of the sleep-wake cycle and insomnia to review recent research and advances in understanding, current treatments for insomnia, and how those new advances might be translated into new, more effective treatments.
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Dual Hypocretin Receptor Antagonism Is More Effective for Sleep Promotion Than Antagonism of Either Receptor Alone
We compared the properties of selective HCRTR1 (SB-408124 and SB-334867) and HCRTR2 (EMPA) antagonists with that of the dual HCRTR1/ R2 antagonist almorexant in the rat.
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Trace Amine-Associated Receptor 1 Partial Agonism Reveals Novel Paradigm for Neuropsychiatric Therapeutics
Here we report on the identification and characterization of the first selective and potent TAAR1 partial agonist.
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Cortical nNOS Neurons Co-Express the NK1 Receptor and are Depolarized by Substance P in Multiple Mammalian Species
To evaluate the degree of co-expression of nNOS and NK1 in the cortex among mammals, we used double immunofluorescence for nNOS and NK1 and determined the anatomical distribution in mouse, rat, and squirrel monkey cortex.
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Acute Optogenetic Silencing of Orexin/Hypocretin Neurons Induces Slow-Wave Sleep in Mice
Our results demonstrate that acute inhibition of orexin neurons results in time-of-day-dependent induction of SWS and in reduced firing rate of neurons in an efferent projection site thought to be involved in arousal state regulation.