Biomedical sciences publications

We report here our forays into the structure–activity relationships for discovering ‘bifunctional’ NOP–mu opioid receptor (MOP) ligands, starting from our NOP-selective scaffolds.

To increase vitamin A coverage in malnourished children, we propose to engineer a probiotic bacterium that will produce β-carotene in the intestine, which will be metabolized to vitamin A.

We show that activation of the trace amine-associated receptor 1 (TAAR1), a modulator of monoaminergic neurotransmission, represents a novel therapeutic option.

Here, we describe the identification of a small molecule activator of HssRS that induces endogenous heme biosynthesis by perturbing central metabolism.

Using an fMRI paradigm, we investigated whether memory performance by alcoholics on a face–name association test previously observed to be problematic for alcoholics could be explained by desynchronous activity between…

To provide a framework for understanding how perturbations in expression of NKRs influence disease pathogenesis, we defined the phenotypic heterogeneity of NK cells in 22 healthy individuals (ages 21-62; M=10,…

Here, we investigate the impact of aging and DJ-1 deficiency in transgenic mice.

The goal of the current study was to understand GPR120 ligand selectivity by testing agonist activity of various fatty acids in cell based assays to measure G-protein activated second messengers,…

SR16388 is a novel amino steroid that targets estrogen-binding proteins including genomic estrogen receptors.