Biomedical sciences publications

The antileishmanial activity of compounds inspired by naphthoquinone secondary metabolites from Bignoniaceae is presented.

Here we present the 1.58 Å structure of Parkin-R0RBR, revealing the fold architecture for the four RING domains, and several unpredicted interfaces.

We show that activation of the trace amine-associated receptor 1 (TAAR1), a modulator of monoaminergic neurotransmission, represents a novel therapeutic option.

To provide a framework for understanding how perturbations in expression of NKRs influence disease pathogenesis, we defined the phenotypic heterogeneity of NK cells in 22 healthy individuals (ages 21-62; M=10,…

Here, we investigate the impact of aging and DJ-1 deficiency in transgenic mice.

Here, we describe the identification of a small molecule activator of HssRS that induces endogenous heme biosynthesis by perturbing central metabolism.

Using an fMRI paradigm, we investigated whether memory performance by alcoholics on a face–name association test previously observed to be problematic for alcoholics could be explained by desynchronous activity between…

Cotinine, a nicotine metabolite, is a biomarker of tobacco, nicotine, and carcinogen exposure. However, a given cotinine level may not represent the same tobacco exposure; for example, African-Americans have higher…

The feasibility of repurposing existing drugs to face novel threats is demonstrated and this represents the first effort to apply this approach to high containment bacteria and viruses.