Biomedical sciences publications
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Importance of the Nicotinic Acetylcholine Receptor System in the Prefrontal Cortex
In this work we review, in light of the latest findings, how nicotinic agonists may be acting in the PFC to influence cognitive function.
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In Vivo Measurement of Aldehyde Dehydrogenase-2 Activity in Rat Liver Ethanol Model Using Dynamic MRSI of Hyperpolarized [1-(13) C] Pyruvate
In this work, we show that dynamic MRSI of hyperpolarized pyruvate and its conversion to [1-13C]lactate can provide an indirect in vivo measurement of ALDH2 activity via the concentration of NADH.
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Polysomnographic Validation of a Wireless Dry Headband Technology for Sleep Monitoring in Healthy Young Adults
The present study aimed to explore the validity and reliability of a wireless dry headband technology for sleep monitoring (WS), through a comparison with concurrent polysomnographic (PSG) recording in healthy…
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A New Perspective for Schizophrenia: TAAR1 Agonists Reveal Antipsychotic- and Antidepressant-Like Activity, Improve Cognition and Control Body Weight
We show that activation of the trace amine-associated receptor 1 (TAAR1), a modulator of monoaminergic neurotransmission, represents a novel therapeutic option.
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Evidence of Oxidative Stress in Young and Aged DJ-1-Deficient Mice
Here, we investigate the impact of aging and DJ-1 deficiency in transgenic mice.
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Network Analysis of the Whole Saliva Transcriptome, Psychosocial Stressor Exposure and Tobacco Use
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Activation of Heme Biosynthesis by a Small Molecule That Is Toxic to Fermenting Staphylococcus Aureus
Here, we describe the identification of a small molecule activator of HssRS that induces endogenous heme biosynthesis by perturbing central metabolism.
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Modulation of Limbic-Cerebellar Functional Connectivity Enables Alcoholics to Recognize Who Is Who
Using an fMRI paradigm, we investigated whether memory performance by alcoholics on a face–name association test previously observed to be problematic for alcoholics could be explained by desynchronous activity between…
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Discovering the Determinants of Diversity in the Human NK Cell Repertoire by Mass Cytometry
To provide a framework for understanding how perturbations in expression of NKRs influence disease pathogenesis, we defined the phenotypic heterogeneity of NK cells in 22 healthy individuals (ages 21-62; M=10,…
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Frequency-Selective Surface Coupled Metal-Oxide-Metal Diodes
In this work we investigate integrating MOM diodes with a slot antenna Frequency Selective Surface (FSS). This maximizes the electromagnetic capture area while minimizing the transmission line length which helps…
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Midbrain-Driven Emotion and Reward Processing in Alcoholism
Enhanced midbrain activation to alcohol-related words suggests neuroadaptation of dopaminergic midbrain systems. We speculate that such tuning is normally associated with behavioral conditioning to optimize responses but here contributed to…
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Pharmacological Characterization of GPR120 Ligands
The goal of the current study was to understand GPR120 ligand selectivity by testing agonist activity of various fatty acids in cell based assays to measure G-protein activated second messengers,…