Biomedical sciences publications
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The Twin Research Registry at SRI International
Twins in the TRR have participated in studies of complex, clinically relevant phenotypes that would not be feasible to measure in larger samples.
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Nighttime Cardiac Sympathetic Hyper-Activation in Young Primary Insomniacs
Impedance cardiography and heart rate variability (HRV) measures were assessed in 9 insomniacs and 9 good sleepers during a night of polysomnographic recording.
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Pharmacogenetic Smoking Cessation Intervention in a Health Care Setting: A Pilot Feasibility Study
We conducted a multiphased, mixed-methods feasibility study with current smokers to develop and evaluate a patient-centered, theoretically grounded personalized medicine treatment protocol.
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Are Women Who Smoke at Higher Risk for Lung Cancer Than Men Who Smoke?
We tested sex-smoking interaction in association with lung cancer risk within a population-based case-control study, the Environment and Genetics in Lung Cancer Etiology (EAGLE) Study (Lombardy, Italy, 2002–2005).
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Evaluation of IL17A Expression and of IL17A, IL17F and IL23R Gene Polymorphisms in Brazilian Individuals with Periodontitis
The aim of present study was to evaluate the expression of IL17A and occurrence of the IL17A (rs2275913), IL17F (rs763780) and IL23R (rs11209026) gene polymorphisms in different clinical forms or…
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Circadian Rhythm Disorders: Does Sex Matter?
There are sex-related differences in circadian rhythms with women having shorter intrinsic periods and earlier phase of both temperature and melatonin rhythms relative to men.
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Retrodialysis of N/Ofq into the Nucleus Accumbens Shell Blocks Cocaine-Induced Increases in Extracellular Dopamine and Locomotor Activity
This study sought to examine the effects of retrodialyzed N/OFQ on the cocaine-induced increase in extracellular dopamine levels in the NAc, as well as locomotor activity, in freely moving rats.
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In Silico Systems Biology Approaches for the Identification of Antimicrobial Targets
We have compiled software tools and databases that are typically used for target identification through in silico analyses. We have also identified enzyme- and broad-spectrum metabolite-based drug targets that have…
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Bed Bug Detection: Current Technologies and Future Directions
Industry surveys report a 100-fold increase in calls for bed bug control, and almost all pest control operations currently respond to bed bug problems.
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Visual Search and the Aging Brain: Discerning the Effects of Age-Related Brain Volume Shrinkage on Alertness, Feature Binding, and Attentional Control
Poorer conjunction, but not feature, search performance was related to older age and volume shrinkage of nodes in the dorsolateral processing stream.
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Cytotoxic Monacolin Analogs from Monascus Purpureus-Fermented Rice
Two new monacolin analogs, monacolins O (1) and P (2), along with three known analogs, have been isolated from the ethanolic extract of Monascus purpureus-fermented rice.
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Incorrect ICBM-DTI-81 Atlas Orientation and White Matter Labels
Unfortunately, in our work using this atlas, we have encountered several substantial problems in terms of (a) correctness of spatial orientation and (b) correctness of white matter tract labels.