Biomedical sciences publications
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How Modulation of Functional Connectivity Between Limbic and Frontocerebellar Circuits from Rest to Task Enables Alcoholics to Recognize Who Is Who
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Sleep-Active Neuronal Nitric Oxide Synthase-Positive Cells of the Cerebral Cortex: a Local Regulator of Sleep?
We review the possible functions of neuronal nitric oxide synthase in regulating neuronal activity, synaptic plasticity and cerebral blood flow within the context of local sleep regulation in the cerebral…
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The Virulence of the Opportunistic Fungal Pathogen Aspergillus Fumigatus Requires Cooperation Between the Endoplasmic Reticulum-Associated Degradation Pathway (Erad) and the Unfolded Protein Response (Upr)
We examined the contribution of these integrated pathways to the growth and virulence of A. fumigatus, focusing on the ERAD protein DerA and the master regulator of the UPR, HacA.
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Patent Ductus Arteriosus Ligation Alters Pulmonary Gene Expression in Preterm Baboons
Ibuprofen-induced ductus closure improves pulmonary mechanics and increases alveolar surface area in premature baboons compared with baboons with a persistent patent ductus arteriosus (PDA).
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Pharmacogenetics of Smoking Cessation in General Practice: Results from the Patch Ii and Patch in Practice Trials
The results and lessons learned from this general practice-based pharmacogenetic research programme provide transportable insights at the transition to the second generation of pharmacogenetic and genomic investigations of smoking cessation…
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Computational Databases, Pathway and Cheminformatics Tools for Tuberculosis Drug Discovery
Cheminformatic techniques have been leveraged and are examined in this review. We suggest that these computational approaches should be optimally integrated within a workflow with experimental approaches to accelerate TB…
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In Vivo MRSI of Hyperpolarized [1-13C]Pyruvate Metabolism in Rat Hepatocellular Carcinoma
We implemented a three-dimensional MRSI sequence to investigate this potential hallmark of cellular metabolism in rat livers bearing HCC (n = 7 buffalo rats).
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Diamino-1,2,4-Triazole Derivatives Are Selective Inhibitors of Tyk2 and Jak1 Over Jak2 and Jak3
Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1–3.
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Neurocircuitry of Emotion and Cognition in Alcoholism: Contributions from White Matter Fiber Tractography
An understanding of the role of cortico-limbic fiber degradation in emotional dysregulation in alcoholism is now emerging.
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Captopril Increases the Intensity of Monocyte Infection By Trypanosoma Cruzi and Induces Human T Helper Type 17 Cells
Here we showed that captopril increases the intensity of T. cruzi infection of human monocytes in vitro. The increased parasitism was accompanied by up-regulated expression of ACE in human monocytes.
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Fiber Tracking Functionally Distinct Components of the Internal Capsule
To examine the microstructural condition of this fiber system and to test functional correlates of its sectors in health and aging, adults were examined with diffusion tensor imaging fiber tracking…
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A. Diamino-1,2,4-Triazole Derivatives are Selective Inhibitors of TYK2 and JAK1 Over JAK2 and JAK3
Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1–3.