Biomedical sciences publications
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Sleep EEG, the Clearest Window Through Which to View Adolescent Brain Development
The paper by Tarokh and colleagues in this issue of SLEEP highlights how longitudinal sleep EEG data is arguably the optimal functional measure of these structural brain changes.
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Utility of a Brief Instrument for Assessing Alcohol Tolerance in Social Drinkers
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A Comparison of in Vivo Neurochemical Sequelae of Binge Alcohol Exposure in Wild-Type Wistar, Alcohol Preferring, and Alcohol Nonpreferring Rats
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A High-Throughput Fluorescence Polarization Assay for Inhibitors of Gyrase B
The assay performed with an average Z′ factor of 0.80 and was able to identify GyrB inhibitors from a screening library.
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Relationship Between Circulating Platelet Counts and Ductus Arteriosus Patency After Indomethacin Treatment
In contrast to the evidence in mice, low circulating platelet counts do not affect permanent ductus closure (or ductus reopening) in human preterm infants.
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Fiber Tracking Functionally Distinct Components of the Internal Capsule
To examine the microstructural condition of this fiber system and to test functional correlates of its sectors in health and aging, adults were examined with diffusion tensor imaging fiber tracking…
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A. Diamino-1,2,4-Triazole Derivatives are Selective Inhibitors of TYK2 and JAK1 Over JAK2 and JAK3
Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1–3.
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Computational Databases, Pathway and Cheminformatics Tools for Tuberculosis Drug Discovery
Cheminformatic techniques have been leveraged and are examined in this review. We suggest that these computational approaches should be optimally integrated within a workflow with experimental approaches to accelerate TB…
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In Vivo MRSI of Hyperpolarized [1-13C]Pyruvate Metabolism in Rat Hepatocellular Carcinoma
We implemented a three-dimensional MRSI sequence to investigate this potential hallmark of cellular metabolism in rat livers bearing HCC (n = 7 buffalo rats).
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Diamino-1,2,4-Triazole Derivatives Are Selective Inhibitors of Tyk2 and Jak1 Over Jak2 and Jak3
Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1–3.
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Neurocircuitry of Emotion and Cognition in Alcoholism: Contributions from White Matter Fiber Tractography
An understanding of the role of cortico-limbic fiber degradation in emotional dysregulation in alcoholism is now emerging.
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Captopril Increases the Intensity of Monocyte Infection By Trypanosoma Cruzi and Induces Human T Helper Type 17 Cells
Here we showed that captopril increases the intensity of T. cruzi infection of human monocytes in vitro. The increased parasitism was accompanied by up-regulated expression of ACE in human monocytes.