Biomedical sciences publications
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Utility of a Brief Instrument for Assessing Alcohol Tolerance in Social Drinkers
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From Biology to Inspiration and Back: Is the Pallidal Complex a Reservoir?
This paper explores parallels between Reservoir Computing models and basal ganglia nuclei including the subthalamic nucleus and globus pallidus.
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In Situ Determination of Total Dissolved Inorganic Carbon By Underwater Membrane Introduction Mass Spectrometry
Factors affecting the response of the membrane introduction mass spectrometer (MIMS) system were examined to optimize calibrations and enhance the accuracy of component ocean carbon system measurements.
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Sheet-Like White Matter Fiber Tracts: Representation, Clustering, and Quantitative Analysis
We introduce an automated and probabilistic method for subject-specific segmentation of sheet-like fiber tracts.
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Sleep EEG, the Clearest Window Through Which to View Adolescent Brain Development
The paper by Tarokh and colleagues in this issue of SLEEP highlights how longitudinal sleep EEG data is arguably the optimal functional measure of these structural brain changes.
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Neurocircuitry of Emotion and Cognition in Alcoholism: Contributions from White Matter Fiber Tractography
An understanding of the role of cortico-limbic fiber degradation in emotional dysregulation in alcoholism is now emerging.
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Captopril Increases the Intensity of Monocyte Infection By Trypanosoma Cruzi and Induces Human T Helper Type 17 Cells
Here we showed that captopril increases the intensity of T. cruzi infection of human monocytes in vitro. The increased parasitism was accompanied by up-regulated expression of ACE in human monocytes.
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Fiber Tracking Functionally Distinct Components of the Internal Capsule
To examine the microstructural condition of this fiber system and to test functional correlates of its sectors in health and aging, adults were examined with diffusion tensor imaging fiber tracking…
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A. Diamino-1,2,4-Triazole Derivatives are Selective Inhibitors of TYK2 and JAK1 Over JAK2 and JAK3
Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1–3.
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Computational Databases, Pathway and Cheminformatics Tools for Tuberculosis Drug Discovery
Cheminformatic techniques have been leveraged and are examined in this review. We suggest that these computational approaches should be optimally integrated within a workflow with experimental approaches to accelerate TB…
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In Vivo MRSI of Hyperpolarized [1-13C]Pyruvate Metabolism in Rat Hepatocellular Carcinoma
We implemented a three-dimensional MRSI sequence to investigate this potential hallmark of cellular metabolism in rat livers bearing HCC (n = 7 buffalo rats).
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Diamino-1,2,4-Triazole Derivatives Are Selective Inhibitors of Tyk2 and Jak1 Over Jak2 and Jak3
Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1–3.