Biomedical sciences publications
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Physiological and Focal Cerebellar Substrates of Abnormal Postural Sway and Tremor in Alcoholic Women
Sway and tremor abnormalities and the selective relations between greater sway and 5 Hz to 7 Hz tremor and smaller volumes of the anterior vermis had not heretofore been described…
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Oral Delivery of Gastro-Resistant Microencapsulated Typhoid Vaccine
The purpose of this study was to develop albumin–chitosan mixed matrix microsphere-filled coated capsule formulations of Typhoid Vi® antigen and to determine whether it can induce antigen-specific mucosal and systemic immune…
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Nociceptin/Orphanin FQ Receptor Activation Attenuates Antinociception Induced By Mixed Nociceptin/Orphanin FQ/Mu-Opioid Receptor Agonists
The ability of the selective NOP receptor antagonist (−)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111) to potentiate antinociception induced by the above compounds was examined to investigate whether activation of NOP receptors leads to attenuation…
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Episodic Memory in Detoxified Alcoholics: Contribution of Grey Matter Microstructure Alteration
These findings support the hypothesis that regional microstructural but no macrostructural alteration of the brain might be responsible, at least in part, for episodic memory deficits in alcohol dependence.
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Diclofenac Potassium Restores Objective and Subjective Measures of Sleep Quality in Women with Primary Dysmenorrhea
We determined the effectiveness of diclofenac potassium, compared to placebo, in alleviating nighttime pain and restoring sleep architecture in women with primary dysmenorrhea.
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Visualizing Implanted Tumors in Mice with Magnetic Resonance Imaging Using Magnetotactic Bacteria
Magnetotactic bacteria can produce positive magnetic resonance imaging contrast and colonize mouse tumor xenografts, providing a potential tool for improved magnetic resonance imaging visualization in preclinical and translational studies to…
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MRI Estimates of Brain Iron Concentration in Normal Aging: Comparison of Field-Dependent (Fdri) and Phase (Swi) Methods
The results showed that both methods detected high globus pallidus iron concentration regardless of age and significantly greater iron in putamen with advancing age.
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Recruitment of CD8(+) T Cells Expressing Granzyme A is Associated with Lesion Progression in Human Cutaneous Leishmaniasis
Our goal was to characterize the immunological kinetics associated with the progression of an infection establishing CL, comparing the cellular composition, cytokines and granzyme expression between lesions of patients with…
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Biology of Charged Particles
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Cellular and Genetic Mechanisms Involved in the Generation of Protective and Pathogenic Immune Responses in Human Chagas Disease
Perhaps one of the most intriguing aspects of human Chagas disease is the complex network of events that underlie the generation of protective versus pathogenic immune responses during the chronic…
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A Novel Peroxisome Proliferator-Activated Receptor Delta Antagonist, SR13904, has Anti-Proliferative Activity in Human Cancer Cells
The peroxisome proliferator-activated receptor delta (PPARδ) is a ligand-activated, nuclear receptor transcription factor that has a documented role in glucose and lipid homeostasis.
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A Systems Biology Network Model for Genetic Association Studies of Nicotine Addiction and Treatment
We discuss several applications of our ontology: to support interdisciplinary research by graphically representing a complex scientific theory, to facilitate meta-analysis across different studies, to highlight potential interactions, and to…