Biomedical sciences publications

Perhaps one of the most intriguing aspects of human Chagas disease is the complex network of events that underlie the generation of protective versus pathogenic immune responses during the chronic…

The peroxisome proliferator-activated receptor delta (PPARδ) is a ligand-activated, nuclear receptor transcription factor that has a documented role in glucose and lipid homeostasis.

We discuss several applications of our ontology: to support interdisciplinary research by graphically representing a complex scientific theory, to facilitate meta-analysis across different studies, to highlight potential interactions, and to…

Selective memory deficits occur in individuals with human immunodeficiency virus (HIV) infection and those with chronic alcoholism, but the potential compounded effect of these conditions is seldom considered, despite the…

The KC incidence and amplitude were negatively impacted in alcoholic men and women with exacerbation of the normal aging effects, particularly over frontal scalp regions.

We explored associations of gene variants in the dopamine, opioid, and serotonin pathways with smoking reward (‘liking’) and reinforcement (latency to first puff and total puffs) as a function of negative mood…

We utilized a cohort of treatment-seeking white cigarette smokers to rank candidate gene single nucleotide polymorphisms associated with the Fagerström Test for Nicotine Dependence.

Preclinical development encompasses the activities that link drug discovery in the laboratory to initiation of human clinical trials.

To mitigate the challenges of small-molecule drug discovery research efforts for the treatment of botulism, we propose product development tools to assist in management of the BoNT portfolio and to…