Biomedical sciences publications
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The Impact of Smoking Cessation and Pharmacotherapy on Sleep Assessed Across the First 10 Days After Quitting
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Regression Models of Atlas Appearance
This paper introduces an appearance modeling framework based instead on generalized multi-linear regression. The training of regression appearance models is controlled by independent variables. This makes it straightforward to create…
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Tobacco Addiction and Pharmacogenetics of Nicotine Metabolism
This paper presents a brief overview of several components of tobacco addiction, including a discussion of progress towards the development of a comprehensive understanding of the pharmacogenetics of tobacco addiction…
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Evoked K-Complex Amplitude Is a Sensitive Marker of Adult Brain Aging
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Adenosinergic and Dopaminergic Signaling as Targets for Wake-Promoting Therapeutics: Insights from Mouse Genetic Models
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Neuroimaging of the Wernicke-Korsakoff Syndrome
Presented is the neuroradiological signature of acute Wernicke's encephalopathy (WE), derived from different types of magnetic resonance imaging (MRI) sequences.
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Opioidergic Projections to Sleep-Active Neurons in the Ventrolateral Preoptic Nucleus
We hypothesized that the influence of opiates on sleep may be mediated, at least in part, by the ventrolateral preoptic nucleus (VLPO), a key cell group for producing behavioral sleep.
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Global-Local Interference Is Related to Callosal Compromise in Alcoholism: a Behavior-DTI Association Study
We used a global–local paradigm to assess component processes of visuospatial ability and MR diffusion tensor imaging (DTI) to examine whether alcoholism-related microstructural degradation of the corpus callosum contributes to…
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Rapid Alterations in Cortical Protein Profiles Underlie Spontaneous Sleep and Wake Bouts
Preliminary microarray analyses show that changes in behavioral state influence regional mRNA profiles; however, the impact of sleep on protein signatures is virtually unexplored. In these studies, cortical protein profiles…
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Correlation of Population Parameters Leading to Power Differences in Association Studies with Population Stratification
We implemented a genetic model for population-based association studies with stratified samples and evaluated the impact on power with different genetic scenarios.
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New Developments in Sleep Research: Molecular Genetics, Gene Expression, and Systems Neurobiology
This mini-symposium review highlights some recent developments at the gene, molecular, cellular, and systems levels that have advanced this field.
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Yeast Bioassay for Identification of Inositol Depleting Compounds
We show here that hexanoic acid, heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, ethylhexanoate, and methyloctanoate decrease intracellular inositol levels and increase the expression of INO1, the gene encoding myo-inositol-3-phosphate synthase…