Biomedical sciences publications
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Long-Term Alcohol Exposure By Vapor Chamber Alters MRS Detectable Metabolites in Rat Striatum
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Hypoxia Signals Autophagy in Tumor Cells Via AMPK Activity, Independent of HIF-1, BNIP3, and BNIP3L
Here we report that oxygen deprivation can activate the autophagic pathway in human cancer cell lines. We observed that hypoxia induced distinct cellular changes characteristic of autophagy such as an…
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Systematic Biological Prioritization After a Genome-Wide Association Study: an Application to Nicotine Dependence
We introduce a method for systematically prioritizing single nucleotide polymorphisms (SNPs) for further study after a GWAS. The method combines evidence across multiple domains including statistical evidence of genotype–phenotype correlation,…
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Diffusion Tensor Tractography in Mesencephalic Bundles: Relation to Mental Flexibility in Detoxified Alcohol-Dependent Subjects
Components of the corticocerebellar circuit and the midbrain individually play a central role in addictive processes and have been associated with altered volumes and impairment of cognitive flexibility in alcohol-dependent…
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Near-Infrared Fluorescent Labeling of Tissue Transglutaminase Substrates for Imaging Tumor Boundaries
A novel strategy is developed to optically image tumor boundaries by cross-linking near-infrared fluorescent-labeled tissue transglutaminase substrates into tumor boundary tissue.
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Microarray Evaluation of the Listeria Monocytogenes Infection and Amoxicillin Treatment in Mice
By using Affymetrix Mouse Genome Arrays and biological replicates, the predictive value of liver and blood gene expression profiles previously identified was validated as predictive of Listeria monocytogenes infection severity.
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Effect of Sleep Stage on Breathing in Children with Central Hypoventilation
Given the differences in anatomy, physiology, and REM sleep distribution between infants and older children, and the reduced number of limb movements during REM sleep, we hypothesized that older subjects…
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Mitochondrial DNA Content: Its Genetic Heritability and Association with Renal Cell Carcinoma
The extent to which mitochondrial DNA (mtDNA) content (also termed mtDNA copy number) in normal human cells is influenced by genetic factors has yet to be established. In addition, whether…
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Ibuprofen-Induced Patent Ductus Arteriosus Closure: Physiologic, Histologic, and Biochemical Effects on the Premature Lung
The goal was to study the pulmonary, biochemical, and morphologic effects of a persistent patent ductus arteriosus in a preterm baboon model of bronchopulmonary dysplasia.
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Towards Digital Representation of Drosophila Embryogenesis
Using Drosophila embryogenesis as a model we are developing molecular, imaging and image analysis techniques to record an entire developmental system at cellular resolution.
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Gene Expression in the Rat Brain During Prostaglandin D2 and Adenosinergically-Induced Sleep
We compared gene expression in the cerebral cortex, basal forebrain, and hypothalamus during PGD2-induced and adenosinergically-induced sleep to results from our previously published study of recovery sleep (RS) after sleep…
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Diffusion Tensor Imaging of Deep Gray Matter Brain Structures: Effects of Age and Iron Concentration
Diffusion tensor imaging (DTI) of the brain has become a mainstay in the study of normal aging of white matter, and only recently has attention turned to the use of DTI…