Biomedical sciences publications
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Homeostatic Sleep Pressure Is the Primary Factor for Activation of Cortical nNOS/NK1 Neurons
Cortical interneurons, immunoreactive for neuronal nitric oxide synthase (nNOS) and the receptor NK1, express the functional activity marker Fos selectively during sleep. NREM sleep ‘pressure’ is hypothesized to accumulate...
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Future Approaches to Therapeutic Hypothermia: A Symposium Report
The current session demonstrates the use of wireless technologies for monitoring several physiological variables in freely moving rodents, and reviews advances in analytical techniques for the detection of adenosine which…
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Plasmodium vivax trophozoite-stage proteomes
Data from two of three biological replicate proteomes, emphasized here, were analyzed using five search engines, which enhanced identifications and resulted in the most comprehensive P. vivax proteomes to date.
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Tablet formulation of an active pharmaceutical ingredient with a sticking and filming problem: direct compression and dry granulation evaluations
Direct compression and dry granulation tableting techniques were evaluated using factorial experimental design.
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Methods of Association and Dissociation for Establishing Selective Brain-Behavior Relations
Methods for identifying and understanding brain structure–function relations have evolved over the past century, from astute observations of selective impairments associated with focal brain damage to dissociations measured by combining…
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Introduction of plasmid encoding for rare tRNAs reduces amplification bias in phage display biopanning
Here we present a method that reduces amplification bias by addition of a plasmid that encodes six low abundance tRNAs into K91 Escherichia coli.
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The Acute Effects of Alcohol on Sleep Electroencephalogram Power Spectra in Late Adolescence
Background Alcohol’s effect on sleep electroencephalogram (EEG) power spectra during late adolescence is of interest given that this age group shows both dramatic increases in alcohol consumption and major sleep-related…
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Sleep in Women: A Review
This article reviews the literature on the characteristics of, and contributing factors to, subjectively and objectively measured sleep during the menstrual cycle, pregnancy, and post-partum period, as well as the…
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Advances in Nanotechnology and Microfluidics for Human Papillomavirus Diagnostics
Here, we review the existing assays and platforms employed for HPV diagnosis, and highlight recent advances in nanotechnology and microfluidics that potentially enable new approaches for HPV diagnosis.
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Controlling Haematophagous Insects: The Quality-of-Life Scenario
This chapter highlights the financial and psychological impact of haematophagous insects in urban environments, using bedbugs as an example. The utility of strategies for vector control in the management of…
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Modular Three-component Delivery System Facilitates HLA Class I Antigen Presentation and CD8(+) T-Cell Activation against Tumors
Here we present a nanoparticle delivery system that facilitates presentation of an immunogenic measles antigen specifically in cancer cells.
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Nitrocobinamide, a New Cyanide Antidote That Can Be Administered by Intramuscular Injection
Here we show that adding sodium nitrite to cobinamide yields a stable derivative that rescues cyanide-poisoned mice and rabbits when given by intramuscular injection.