Biomedical sciences publications
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USP8 Regulates Mitophagy by Removing K6-Linked Ubiquitin Conjugates from Parkin
We report here that USP8/UBPY, a deubiquitinating enzyme not previously implicated in mitochondrial quality control, is critical for parkin-mediated mitophagy.
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Blockade of α6* nAChR Reduces L-Dopa-Induced Dyskinesias; Studies Using Parkinsonian α6* nAChR Gain-of-Function Mice
To understand the mechanism through which α6β2* nAChRs regulate L-dopa-induced AIMs, we used gain-of-function α6* nAChR (α6L9’S) mice. This mutation results in enhanced sensitivity to nicotine/acetylcholine and prolonged receptor-mediated activity.
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Evidence of Reporting Biases in Voxel-Based Morphometry (VBM) Studies of Psychiatric and Neurological Disorders
Objective: To evaluate whether biases may influence the findings of whole-brain structural imaging literature.
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Imaging Neuroinflammation? A Perspective from MR Spectroscopy
The present MRS study was conducted in four groups: alcohol dependent, HIV-infected, alcohol dependent + HIV infected and healthy control individuals to determine whether metabolites would change in a pattern reflecting neuroinflammation.
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(R,S)-Ketamine Metabolites (R,S)-Norketamine and (2S,6S)-Hydroxynorketamine Increase the Mammalian Target of Rapamycin Function
Subanesthetic doses of (R,S)-ketamine are used in the treatment of neuropathic pain and depression.
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miRNA and Autophagy in the Pharmacological Gaucher Mouse Model
This study investigates early stage pathogenetic targets that contribute to degeneration in Gaucher disease, Parkinson’s disease (PD) and Gaucher-related PD.
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Brain Metabolite Levels as Predictors of Abstinance or Relapse in Alcohol Use Disorders
This in vivo magnetic resonance spectroscopy study included 15 control subjects and 20 recently sober individuals with alcohol use disorders.
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Varenicline Enhances Dopamine Release Facilitation after Long-Term Nicotine Treatment and Withdrawal
Here, we used real-time cyclic voltammetry in brain slices containing the nucleus accumbens to further elucidate the changes in dopamine release linked to nicotine withdrawal.
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The α7 nicotinic receptor agonist ABT-107 decreases L-Dopa-induced dyskinesias in parkinsonian monkeys
Since rodent studies also suggested an involvement of α7 nAChRs in LIDs, we tested the effect of the potent, selective α7 agonist ABT-107 [5-(6-[(3R)-1-azabicyclo[2.2.2]oct-3-yloxy] pyridazin-3-yl)-1H-indole].
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Folate and Vitamin B12 May Play a Critical Role in Lowering the HPV 16 Methylation-Associated Risk of Developing Higher Grades of CIN
The purpose of the current study was to replicate our previous findings and to evaluate the influence of plasma concentrations of folate and vitamin B12 on the degree of HPV…
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Novel Human Radiation Exposure Biomarker Panel Applicable for Population Triage
We aimed to identify a panel of radiation-responsive plasma proteins that could be used in a point-of-care biologic dosimeter to detect clinically significant levels of ionizing radiation exposure
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The α7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions.
The finding that smoking is inversely correlated with Parkinson’s disease and that nicotine attenuates nigrostriatal damage in Parkinsonian animals supports the idea that nicotine may be neuroprotective.