Biomedical sciences publications
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Smoking and Genetic Risk Variation Across Populations of European, Asian, and African American Ancestry–a Meta-Analysis of Chromosome 15q25
We demonstrate association between smoking quantity and markers in the chromosome 15q25 region across all three populations, and narrow the region of association.
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Metabolism, Pharmacokinetics, Tissue Distribution, and Stability Studies of the Prodrug Analog of an Anti-Hepatitis B Virus Dinucleoside Phosphorothioate
The preferential distribution of the dinucleotide 1 and its prodrug 2 into liver may be attributed to the presence of nucleoside phosphorothioate backbone because phosphorothioate oligonucleotides also reveal a similar…
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N-Glycan Cryptic Antigens as Active Immunological Targets in Prostate Cancer Patients
We report here a carbohydrate microarray analysis of a number of tumor-associated carbohydrates for their serum antibody reactivities and potential immunogenicity in humans
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Heightened Awareness in Insomnia
... investigate the possibility of hyperarousal in insomnia leading to the possibility of conscious awareness occurring in the context of what we have traditionally viewed to be EEG evidence of…
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Effects of Bacterial and Presystemic Nitroreductase Metabolism of 2-Chloro-5-Nitro-N-Phenylbenzamide on its Mutagenicity and Bioavailability
Studies were initiated to assess its bacterial mutagenicity and pharmacokinetic profile in two animal species prior to subchronic oral toxicity evaluations and the results are reported here.
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Evaluation of Arylimidamides DB1955 and DB1960 as Candidates Against Visceral Leishmaniasis and Chagas’ Disease: In Vivo Efficacy, Acute Toxicity, Pharmacokinetics, and Toxicology Studies
These two mesylate salts exhibited dose-dependent activity in the murine model of VL, with DB1960 inhibiting liver parasitemia and DB1955 reducing liver parasitemia.
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Design Considerations for Liposomal Vaccines: Influence of Formulation Parameters on Antibody and Cell-Mediated Immune Responses to Liposome Associated Antigens
We present a comprehensive review of the physicochemical properties of liposomal vaccines and how they influence immune responses. A discussion of novel and emerging immunomodulators that are suitable for inclusion…
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Thermodynamics and Docking of Agonists to the β 2- Adrenoceptor Determined Using [ 3H](R,R′)-4-Methoxyfenoterol as the Marker Ligand
To better understand the molecular interactions of fenoterol analogs with the β2-adrenergic receptor, we developed a new agonist radioligand for binding assays.
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Nicotine Reduces Antipsychotic-Induced Orofacial Dyskinesia in Rats
In this study, we investigated whether nicotine administration could reduce tardive dyskinesia because nicotine attenuates other drug-induced abnormal movements.
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Ionizing Radiation Regulates the Expression of AMP-Activated Protein Kinase (AMPK) in Epithelial Cancer Cells: Modulation of Cellular Signals Regulating Cell Cycle and Survival
Purpose:To analyze the expression of AMPK in a variety of epithelial cancer cells, regulation of AMPK subunit expression by ionizing radiation and impact of AMPK on signaling pathways regulating cell…
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The ST Pinch: A Side Chain-to-Side Chain Hydrogen-Bonded Motif
The ST Pinch is a 12-membered hydrogen-bonded motif (Ser/Thr-Xaa-Ser/Thr) involving the side chain oxygen atoms of two Ser/Thr residues. We identified the ST Pinch in 104 proteins in a database…
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Gene-Centric Analysis of Serum Cotinine Levels in African and European American Populations
We conducted a genetic association study of the biomarker in African American and European American subjects from the Coronary Artery Risk Development in Young Adults study using a chip containing…