Biomedical sciences publications
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Genome-Wide Meta-analyses of Smoking Behaviors in African Americans
Here we report results of the first genome-wide association study meta-analysis of smoking behavior in African Americans in the Study of Tobacco in Minority Populations Genetics Consortium.
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Synthesis of a 35S-Labeled Dinucleoside Phosphorothioate Prodrug, an Orally Bioavailable Anti-HBV Agent
The 35S-labeled, dinucleoside phosphorothioate 1, an orally available agent against hepatitis B virus, was prepared in eight steps with high specific activity and radiochemical purity.
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Evaluation of Arylimidamides DB1955 and DB1960 as Candidates Against Visceral Leishmaniasis and Chagas’ Disease: In Vivo Efficacy, Acute Toxicity, Pharmacokinetics, and Toxicology Studies
These two mesylate salts exhibited dose-dependent activity in the murine model of VL, with DB1960 inhibiting liver parasitemia and DB1955 reducing liver parasitemia.
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N-Glycan Cryptic Antigens as Active Immunological Targets in Prostate Cancer Patients
We report here a carbohydrate microarray analysis of a number of tumor-associated carbohydrates for their serum antibody reactivities and potential immunogenicity in humans
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Heightened Awareness in Insomnia
... investigate the possibility of hyperarousal in insomnia leading to the possibility of conscious awareness occurring in the context of what we have traditionally viewed to be EEG evidence of…
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Effects of Bacterial and Presystemic Nitroreductase Metabolism of 2-Chloro-5-Nitro-N-Phenylbenzamide on its Mutagenicity and Bioavailability
Studies were initiated to assess its bacterial mutagenicity and pharmacokinetic profile in two animal species prior to subchronic oral toxicity evaluations and the results are reported here.
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Lead Optimization of 3-Carboxyl-4(1 H)-Quinolones to Deliver Orally Bioavailable Antimalarials
Herein, we report the lead optimization of 4(1H)-quinolones with a focus on improving both antimalarial potency and bioavailability.
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Design Considerations for Liposomal Vaccines: Influence of Formulation Parameters on Antibody and Cell-Mediated Immune Responses to Liposome Associated Antigens
We present a comprehensive review of the physicochemical properties of liposomal vaccines and how they influence immune responses. A discussion of novel and emerging immunomodulators that are suitable for inclusion…
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Thermodynamics and Docking of Agonists to the β 2- Adrenoceptor Determined Using [ 3H](R,R′)-4-Methoxyfenoterol as the Marker Ligand
To better understand the molecular interactions of fenoterol analogs with the β2-adrenergic receptor, we developed a new agonist radioligand for binding assays.
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Nicotine Reduces Antipsychotic-Induced Orofacial Dyskinesia in Rats
In this study, we investigated whether nicotine administration could reduce tardive dyskinesia because nicotine attenuates other drug-induced abnormal movements.
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Ionizing Radiation Regulates the Expression of AMP-Activated Protein Kinase (AMPK) in Epithelial Cancer Cells: Modulation of Cellular Signals Regulating Cell Cycle and Survival
Purpose:To analyze the expression of AMPK in a variety of epithelial cancer cells, regulation of AMPK subunit expression by ionizing radiation and impact of AMPK on signaling pathways regulating cell…
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The ST Pinch: A Side Chain-to-Side Chain Hydrogen-Bonded Motif
The ST Pinch is a 12-membered hydrogen-bonded motif (Ser/Thr-Xaa-Ser/Thr) involving the side chain oxygen atoms of two Ser/Thr residues. We identified the ST Pinch in 104 proteins in a database…