Biomedical sciences publications
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Design Considerations for Liposomal Vaccines: Influence of Formulation Parameters on Antibody and Cell-Mediated Immune Responses to Liposome Associated Antigens
We present a comprehensive review of the physicochemical properties of liposomal vaccines and how they influence immune responses. A discussion of novel and emerging immunomodulators that are suitable for inclusion…
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Nicotine Reduces Antipsychotic-Induced Orofacial Dyskinesia in Rats
In this study, we investigated whether nicotine administration could reduce tardive dyskinesia because nicotine attenuates other drug-induced abnormal movements.
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Thermodynamics and Docking of Agonists to the β 2- Adrenoceptor Determined Using [ 3H](R,R′)-4-Methoxyfenoterol as the Marker Ligand
To better understand the molecular interactions of fenoterol analogs with the β2-adrenergic receptor, we developed a new agonist radioligand for binding assays.
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Peptides Derived from the Prohormone proNPQ/Spexin are Potent Central Modulators of Cardiovascular and Renal Function and Nociception
Here we demonstrate biological activity for two peptides present within proNPQ/spexin. NPQ/spexin and NPQ 53–70 have differing renal and cardiovascular effects when administered intracerebroventricularly or intravenously into rats.
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Moving “Forward” in Plasmodium Genetics Through a Transposon-Based Approach
The introduction of forward genetics has provided novel means to gain a better understanding of gene functions and their associated phenotypes in Plasmodium.
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Hemopressin Forms Self-Assembled Fibrillar Nanostructures Under Physiologically Relevant Conditions
On the basis of hemopressin’s potential in therapeutic applications and the lack of a structure–activity relationship study in literature, we aimed to determine the conformational features of hemopressin under physiological…
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MRI Estimates of Brain Iron Concentration in Normal Aging Using Quantitative Susceptibility Mapping
We use recently-developed Quantitative Susceptibility Mapping (QSM) methodology to estimate the tissue magnetic susceptibility based on MRI signal phase.
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Partial Recovery of Alcohol Dependence-Related Deficits in Sleep Evoked Potentials Following 12 Months of Abstinence
The present study tested the hypothesis that the amplitude of K-complex related evoked potential components would increase with prolonged abstinence from alcohol.
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Refinement of Structural Leads for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases
We present a systematic structural optimization of uncharged but ionizable N-substituted 2-hydroxyiminoacetamido alkylamine reactivators of phosphylated human acetylcholinesterase (hAChE) intended to catalyze the hydrolysis of organophosphate (OP)-inhibited hAChE in the CNS.
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Developmental Changes in the Sleep Electroencephalogram of Adolescent Boys and Girls
The present study seeks to resolve some of these issues in a combined cross-sectional and longitudinal analysis of sleep EEG in adolescents.
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Perceived Poor Sleep Quality in the Absence of Polysomnographic Sleep Disturbance in Women with Severe Premenstrual Syndrome
This study evaluated sleep quality subjectively and objectively using polysomnographic and quantitative electroencephalographic measures in women with severe premenstrual syndrome.
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Carbohydrate Antigen Microarrays
This chapter describes one of my laboratory’s working protocols for carbohydrate-based microarrays.