Biomedical sciences publications
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Impact of X Chromosome Genes in Explaining the Excess Risk of Cancer in Males
The authors examined cancer incidence sex ratios in Denmark for 1943–2003 by age group. At nongenital/nonbreast sites, incidences were consistently higher in males.
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Modulation of Luciferase Activity Using High Intensity Focused Ultrasound in Combination with Bioluminescence Imaging, Magnetic Resonance Imaging and Histological Analysis in Muscle Tissue
This study investigates the effect of high intensity focused ultrasound (HIFU) to muscle tissue transfected with a luciferase reporter gene under the control of a CMV-promoter.
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Genetic and Environmental Influences on the Ratio of 3’Hydroxycotinine to Cotinine in Plasma and Urine
This analysis sought to conduct a combined genetic epidemiologic and pharmacogenetic investigation of the 3HC/COT ratio in plasma and urine.
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Simultaneous Quantification of Perfusion and Permeability in the Prostate Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging with an Inversion-Prepared Dual-Contrast Sequence
The aim of the present study was to quantify both perfusion and extravasation in the prostate to discriminate tumor from healthy tissue, which might be achieved by dynamic contrast-enhanced magnetic…
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Degradation of Association and Projection White Matter Systems in Alcoholism Detected with Quantitative Fiber Tracking
Alcoholism affected FA and diffusivity, particularly λT, of several fiber bundles. Frontal and superior sites (frontal forceps, internal and external capsules, fornix, and superior cingulate and longitudinal fasciculi) showed greatest…
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Development of a Transillumination Infrared Modality for Differential Vasoactive Optical Imaging
We present the development and implementation of a new near infrared transillumination imaging modality for tissue imaging. Exogenous inhaled hyperoxic and hypercarbic gases are used as "vasoactive contrast agents" via…
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Pharmacokinetics of Nikkomycin Z After Single Rising Oral Doses
Nikkomycin Z is an antifungal drug that inhibits chitin synthase. This agent is under development as an orphan product for treatment of coccidioidomycosis.
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Selective Loss of Gabab Receptors in Orexin-Producing Neurons Results in Disrupted Sleep/Wakefulness Architecture
Here we analyze the in vivo and in vitro phenotype of mice lacking the GABAB1 gene specifically in orexin neurons (oxGKO mice) and demonstrate that GABAB receptors on orexin neurons are essential in stabilizing and consolidating sleep/wake…
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Expression of Neuronal Calcium Sensor-1 (NCS-1) is Decreased in Leukocytes of Schizophrenia and Bipolar Disorder Patients
We sought to investigate the NCS-1 expression in lymphocytes and monocytes (CD4+ T lymphocytes, CD56+ NK cells, CD19+ B lymphocytes and CD14+ monocytes) of SCZ and BPD patients.
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Chronic in Utero Cyclooxygenase Inhibition Alters PGE2-Regulated Ductus Arteriosus Contractile Pathways and Prevents Postnatal Closure
We used fetal mice and sheep to determine whether PGE2 has a role in the development of ductus contractility that is distinct from its function as a vasodilator.
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Pathway Analysis By Adaptive Combination of P-Values
Building upon existing P-value combining methods, we propose a class of highly flexible pathway analysis approaches based on an adaptive rank truncated product statistic that can effectively combine evidence of associations…
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Thyrotropin-Releasing Hormone Increases Behavioral Arousal Through Modulation of Hypocretin/Orexin Neurons
In vitro electrophysiological studies showed that bath application of TRH caused concentration-dependent membrane depolarization, decreased input resistance, and increased firing rate of identified Hcrt neurons.