Publications
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Aversive and Reinforcing Opioid Effects: A Pharmacogenomic Twin Study
Gaining a better understanding of the genetic and environmental mechanisms contributing to an individual's susceptibility to adverse opioid effects is essential to identify patients at risk.
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Quantification of Glutamate and Glutamine Using Constant-Time Point-Resolved Spectroscopy at 3 T
To quantify Glu and Gln, a time-domain basis set was constructed taking into account metabolite T 2 relaxation times and dephasing from B 0 inhomogeneity.
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Two SHIPs Passing in the Middle of the Immune System
Using conditional knockouts of SHIP1 in either the myeloid or T-cell-lineage of mice, the authors show that the regulated development of Treg cells is controlled directly by cell-intrinsic SHIP1, and…
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Unpacking the Black Box of Engagement: Cognitive, Behavioral, and Affective Engagement in Learning Mathematics
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Long-Term Behavioral, Electrophysiological, and Neurochemical Monitoring of the Safety of an Experimental Antiepileptic Implant, the Muscimol-Delivering Subdural Pharmacotherapy Device in Monkeys Laboratory Investigation
The authors evaluated the extent to which the Subdural Pharmacotherapy Device (SPD), chronically implanted over the frontal cortex to perform periodic, localized muscimol-delivery/CSF removal cycles, affects overall behavior, motor performance,…
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Socio-linguistic decisions and gender mapping across real and virtual world cultures
This study examines a large corpus of online gaming chat and avatar names to explore gender differences in virtual world (VW) language use.
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Pain Sensitivity and Opioid Analgesia: a Pharmacogenomic Twin Study
This study used a twin paradigm to provide a global estimate of the genetic and environmental contributions to inter-individual differences in pain sensitivity and analgesic opioid effects.
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Cannabinoid Receptor Activation Correlates with the Proapoptotic Action of the beta(2)-Adrenergic Agonist (R,R ‘)-4-Methoxy-1-Naphthylfenoterol in HepG2 Hepatocarcinoma Cells
We compare the effect of the β2-AR agonists (R,R′)-fenoterol (Fen) and (R,R′)-4-methoxy-1-naphthylfenoterol (MNF) on signaling and cell proliferation in HepG2 hepatocarcinoma cells by using Western blotting and [3H]thymidine incorporation assays.
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Genotoxicity of the Cancer Chemopreventive Drug Candidates CP-31398, SHetA2, and Phospho-Ibuprofen
The genotoxic activities of three cancer chemopreventive drug candidates, CP-31398 (a cell permeable styrylquinazoline p53 modulator), SHetA2 (a flexible heteroarotinoid), and phospho-ibuprofen (PI, a derivative of ibuprofen) were tested.
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Multiple Target Tracking by Integrating Track Refinement and Data Association
Multiple target tracking that integrates target model estimation and data association steps is described. The integration allows successive refinement of the models while reducing the uncertainty in data association.
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Rodent Motor and Neuropsychological Behaviour Measured in Home Cages Using the Integrated Modular Platform SmartCage ™
To facilitate investigation of diverse rodent behaviours in rodents’ home cages, we have developed an integrated modular platform, the SmartCage™ system (AfaSci, Inc. Burlingame, CA, USA), which enables automated neurobehavioural phenotypic…
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Highly Conserved CDR3 Region in Circulating CD4(+)V Beta 5(+) T Cells may be Associated with Cytotoxic Activity in Chagas Disease
The aim of this work was to determine whether T cells expressing this particular Vβ region displayed variable or restricted CDR3 sequences, as an indicator of the nature of the…