SRI International
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Pathway Size Matters: The Influence of Pathway Granularity on Over-Representation (Enrichment) Statistics
We show that alternative pathway definitions can alter enrichment p -values by up to nine orders of magnitude, whereas statistical corrections typically alter enrichment p -values by only two orders of magnitude.
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Leveraging Curation Among Escherichia coli Pathway/Genome Databases Using Ortholog-Based Annotation Propagation
We have developed a method to automatically propagate multiple types of curated knowledge from genes and proteins in one genome database to their orthologs in uncurated databases for related strains, imposing several quality-control filters to reduce the chances of introducing errors.
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Prediction of Selected Biosynthetic Pathways for the Lipopolysaccharide Components in Porphyromonas gingivalis
We use bioinformatics tools to predict biosynthetic pathways for the production of the normal (O-type) lipopolysaccharide in the W50 strain Porphyromonas gingivalis and compare the pathway with other putative pathways in fully sequenced and completed genomes of other pathogenic strains.
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Physiological Responses to Acute Psychosocial Stress in Women with Menopausal Insomnia
Insomnia disorder is a common sleep disorder and frequently emerges in the context of menopause, being associated with menopause-specific factors such as hot flashes and other psychosocial variables.
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Sleep and Circadian Regulation of the Autonomic Nervous System
The ANS is under the influence of circadian and sleep-dependent modulation. Forced desynchrony and constant routine protocols indicate strong circadian influences on heart rate and cardiac vagal activity.
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Featured innovator: Samson Phan
SRI senior research engineer is leading exciting advancements in space robotics
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Expanding cancer immunotherapy by exploiting recall immunity – a new co-therapy option for checkpoint inhibitor
SRI International has developed a novel immunotherapy that is capable of delivering previously encountered antigenic peptides specifically to cancer cells and facilitating their presentation through the MHC class I pathway.
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Early Childhood Education During the COVID-19 Pandemic: The Experiences of Arkansas Educators
SRI International and the National Center on Children in Poverty collected information on how Arkansas early care providers are implementing state COVID-19-related guidelines and coping with the challenges related to these guidelines.
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National Effectiveness Study of First Step to Success
SRI conducted a large-scale study of the effectiveness of an early intervention program intended to help young children at risk for developing antisocial or aggressive behaviors.
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Efficacy Study of Check & Connect to Improve Student Outcomes
Check & Connect (C&C) is a comprehensive, manualized student engagement intervention developed to promote school success and completion for secondary school students at high risk of school failure and dropout
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Students Exposed to Trauma: A Study of the CBITS Program
SRI researchers are conducting a study of the efficacy of the Cognitive Behavioral Intervention for Trauma in Schools (CBITS) program.
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75 Years of Innovation: Handwriting recognition
The ability to verify handwritten signatures in real-time