SRI International
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Design and Verification for Transportation System Security
In this work, we propose an integrated framework that combines hybrid modeling, formal verification, and automated synthesis techniques for analyzing the security and safety of transportation systems and carrying out design space exploration of both in-vehicle electronic control systems and vehicle-to-vehicle communications.
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Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery
We have demonstrated how combining chemoinformatics and bioinformatics for T. cruzi drug discovery can bring interesting in vivo active molecules to light that may have been overlooked.
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Clock Genes X Stress X Reward Interactions in Alcohol and Substance Use Disorders
The aim of the present review is to summarize findings linking clock genes, stress, and alcohol and substance abuse, and to propose potential underlying neurobiological mechanisms.
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Multi-step Hydrothermal Liquefaction (HTL) of Algae with Nutrient Recycling
A presentation of SRI research to meet the need of a thermochemical process that allows economic conversion of wet biomass to liquid fuels.
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Spatial and Temporal Patterns in Preterm Birth in the United States
In order to help generate new research hypotheses, this study explored spatial and temporal patterns of preterm birth in a large, total-population dataset.
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Characterization of Batracylin-Induced Renal and Bladder Toxicity in Rats
To further investigate batracylin’s mechanism of toxicity, studies were conducted in Fischer 344 rats. Once daily oral administration of 16 or 32 mg/kg batracylin to rats for 4 days caused overt toxicity.
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Evaluation of the Florida Master Teacher Initiative Final Evaluation Findings
The purpose of this study was to examine the impact of the Florida Master Teacher Initiative (FMTI)–an i3-funded early learning program aimed at improving the quality of teaching and student outcomes in grades PreK through third grade in high need schools.
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Addiction, Freedom, and Responsibility
In his article supporting an evolutionary perspective of free will, John Banja (2015) argues that addicts are responsible for their addictive behaviors because they could engage in practices that would diminish the chances that they would act on their cravings.
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Bioprotective Carnitinoids: Lipoic Acid, Butyrate, and Mitochondria-Targeting to Treat Radiation Injury: Mitochondrial Drugs Come of Age
There is an urgent need for effective medicines to protect against and treat the harmful biological effects of radiation . Potential strategies herein include mitochondrial and epigenetic-driven methods using lipoic and butyric acid ester conjugates of carnitine and more.
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Evidence for a Role for alpha6 nAChRs in L-Dopa-Induced Dyskinesias Using Parkinsonian alpha6 nAChR Gain-of-Function Mice
Here we investigate the role of α6β2* nAChRs, a subtype selectively present in the nigrostriatal pathway, using α6 nAChR subunit null mutant (α6(-/-)) mice.
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High School Math and Science Preparation and Postsecondary STEM Participation for Students with an Autism Spectrum Disorder
This study analyzed data from the National Longitudinal Transition Study–2, a nationally representative sample of students with an ASD in special education in the United States.
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Lack of School Nurses in California Puts School Children at Risk
Much of the work we do at SRI Education looks at policies and their effects on children and youth, especially those at risk for academic failure because of poverty or disability. Research has long established that children with special health care needs are at increased risk of school failure for a number of reasons including…