SRI International
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Characterization of cyclic peptides containing disulfide bonds
Three peptides that belong to this category, p-Cl-Phe-DPDPE, DPDPE, and CTOP, were analyzed and the results are presented in this paper.
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Designing for Deeper Learning in a Blended Computer Science Course for Middle School Students
The focus of this research was to create and test an introductory computer science course for middle school. Titled “Foundations for Advancing Computational Thinking” (FACT), the course aims to prepare and motivate middle school learners for future engagement with algorithmic problem solving.
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Weakness in Depth: A Voting Machine’s Demise
Virginia’s government recently examined the AVS WinVote and learned that the vulnerabilities are more serious than any other voting system, allowing complete exploitation over a Wi-Fi network.
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Practical Measures of Learning Behaviors
This paper argues that improving learning reliably and at scale requires a specific orientation toward measurement, understood broadly.
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Classification of Lexical Stress Using Spectral and Prosodic Features for Computer-assisted Language Learning Systems
We present a system for detection of lexical stress in English words spoken by English learners. This system was designed to be part of the EduSpeak® computer-assisted language learning (CALL) software.
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Model Demonstration Projects: Sustainability and Scale-Up (Presentation Abstract)
The aim of this presentation was to share SRI Education’s findings on sustainment and scale-up of model demonstration projects funded by the U.S. Department of Education, Office of Special Education Programs, conducted as part of the Model Demonstration Coordination Center.
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Pharmacological Characterization of RO5461861, a Potent and Selective PDE10A Inhibitor
We describe the characterization of a new class of potent PDE10A inhibitors exemplified by 4-(Azetidine-1 -carbonyl)-2-methyl-2-H-pyrazole-3-carboxylic acid (2-phenylimidazo[1,2-a]pyrimidin-7-yl)-amide (RO5461861) in vitro as well as in behavioral tests relevant to NMDA-R hypofunction and working memory.
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Biodistribution of the Multidentate Hydroxypyridinonate Ligand [(14) C]-3,4,3-Li(1,2-HOPO), a Potent Actinide Decorporation Agent
The pharmacokinetics and biodistribution of the 14C-labeled actinide decorporation agent 3,4,3-LI(1,2-HOPO) were investigated in young adult Swiss Webster mice and Sprague Dawley rats, after intravenous, intraperitoneal, and oral dose administration.
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High Frequency Neuronal Oscillations in a Cynomolgus Macaque Test of Working Memory Following NMDA Receptor Antagonism
Disruptions in sensory processing and abnormal temporal integration of neuronal oscillations have been identified in schizophrenic patients and may contribute to poor performance in working memory task testing.
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Assessments for Computational Thinking in K-12
This paper argues for the need for multiple measures or “systems of assessments” that are complementary, attend to cognitive and non-cognitive aspects of CT, and contribute to a comprehensive picture of student learning.
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Anomaly Detection and Diagnosis for Automatic Radio Network Verification
This paper focuses on the verification problem, proposing a novel framework that uses anomaly detection and diagnosis techniques that operate within a specified spatial scope.
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Reduced Cerebral and Cardiovascular Hemodynamics During Sustained Affective Stimulation in Young Women with Chronic Low Blood Pressure
We assessed central and peripheral hemodynamic changes in 15 undergraduate women with chronic hypotension and 15 normotensive controls during sustained exposure to pleasant, unpleasant and neutral pictures.