Biomedical sciences publications

Here, using docking simulation and site-directed mutagenesis, we defined Tyr-308 as the key amino acid residue on β2-AR essential for Gs-biased signaling.

We evaluated time to clearance of high risk (HR) HPV infection in relation to functional variants in three genes (CYP1A1, GSTT1, and GSTM1).

Our results suggest that acute administration of a NMDA receptor antagonist disrupts neuronal oscillations and cognitive processing and this may contribute to impaired cognitive performance in macaques.

We hypothesized that besides quantitative transcriptional effects, HTLV-1 qualitatively modifies the pattern of cellular gene expression.

To identify new cardiac biomarkers, a quantitative proteomic analysis has been performed on serum and heart tissue proteins from three species of nonhuman primates following isoproterenol (ISO) treatment.

We evaluated endoxifen using a classic uterotrophic effects method.

We tested the hypothesis that alcoholic patients would demonstrate compromised dorsal anterior cingulate cortex (dACC) -cerebellar functional connectivity when adjusting their strategies to accommodate uncertain conditions and would recruit compensatory…

The main objective of this investigation was to study the feasibility of developing a vaginal bioadhesive microbicide using a SRI’s proprietary two-polymer gel platform (SR-2P).

The presence of physiological hot flashes accounts for a significant proportion of total objective time awake during the night in perimenopausal women.

We evaluated chr6q25.3 organic cation transporter gene (SLC22A1, SLC22A2, SLC22A3) variation and response to smoking cessation therapies.

Using a peer nomination technique in a sample of incarcerated females, our study is the first to examine the association between peer status and psychopathology in a correctional facility.

To understand the mechanism through which α6β2* nAChRs regulate L-dopa-induced AIMs, we used gain-of-function α6* nAChR (α6L9’S) mice. This mutation results in enhanced sensitivity to nicotine/acetylcholine and prolonged receptor-mediated activity.