Biomedical sciences publications
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The Ability of Plasma Cotinine to Predict Nicotine and Carcinogen Exposure Is Altered by Differences in CYP2A6: The Influence of Genetics, Race, and Sex
Cotinine, a nicotine metabolite, is a biomarker of tobacco, nicotine, and carcinogen exposure. However, a given cotinine level may not represent the same tobacco exposure; for example, African-Americans have higher…
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Preparation and Spectroscopic Characterization of Chemical Derivatives of Lawsone: Novel Reagents to Detect Fingerprints
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A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents
The feasibility of repurposing existing drugs to face novel threats is demonstrated and this represents the first effort to apply this approach to high containment bacteria and viruses.
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Frequency-Selective Surface Coupled Metal-Oxide-Metal Diodes
In this work we investigate integrating MOM diodes with a slot antenna Frequency Selective Surface (FSS). This maximizes the electromagnetic capture area while minimizing the transmission line length which helps…
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Midbrain-Driven Emotion and Reward Processing in Alcoholism
Enhanced midbrain activation to alcohol-related words suggests neuroadaptation of dopaminergic midbrain systems. We speculate that such tuning is normally associated with behavioral conditioning to optimize responses but here contributed to…
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Pharmacological Characterization of GPR120 Ligands
The goal of the current study was to understand GPR120 ligand selectivity by testing agonist activity of various fatty acids in cell based assays to measure G-protein activated second messengers,…
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SR16388 Impairs Protein Homeostasis and Induces Autophagy in Diverse Human Cancer Cell Lines
SR16388 is a novel amino steroid that targets estrogen-binding proteins including genomic estrogen receptors.
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Anti-Oligomannose Antibodies as Potential Serum Biomarkers of Aggressive Prostate Cancer
This study bridges a carbohydrate microarray discovery and a large-scale serological validation of anti-oligomannose antibodies as novel serum biomarkers of aggressive prostate cancer.
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The Nicotine-Mediated Decline in L-Dopa-Induced Dyskinesias Is Associated with a Decrease in Striatal Dopamine Release
This study investigates whether nicotine may exert its beneficial effects by modulating pre-synaptic dopaminergic function.
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Comorbidity of Alcoholism, HIVInfection and Hepatitis C: In Vivo Brain Imaging
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Biomarkers—an Essential Tie That Binds the Future of Drugs and Diagnostics
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Alzheimer’s Disease Biomarkers: More Than Molecular Diagnostics
This review assesses progress in a number of areas of AD biomarker discovery and development, constituting a potential systems approach to understanding and diagnosing this disease.