Biomedical sciences publications
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A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents
The feasibility of repurposing existing drugs to face novel threats is demonstrated and this represents the first effort to apply this approach to high containment bacteria and viruses.
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Frequency-Selective Surface Coupled Metal-Oxide-Metal Diodes
In this work we investigate integrating MOM diodes with a slot antenna Frequency Selective Surface (FSS). This maximizes the electromagnetic capture area while minimizing the transmission line length which helps…
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Midbrain-Driven Emotion and Reward Processing in Alcoholism
Enhanced midbrain activation to alcohol-related words suggests neuroadaptation of dopaminergic midbrain systems. We speculate that such tuning is normally associated with behavioral conditioning to optimize responses but here contributed to…
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Pharmacological Characterization of GPR120 Ligands
The goal of the current study was to understand GPR120 ligand selectivity by testing agonist activity of various fatty acids in cell based assays to measure G-protein activated second messengers,…
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SR16388 Impairs Protein Homeostasis and Induces Autophagy in Diverse Human Cancer Cell Lines
SR16388 is a novel amino steroid that targets estrogen-binding proteins including genomic estrogen receptors.
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Genetic Analysis of a Population Heavy Drinking Phenotype Identifies Risk Variants in Whites
This proof-of-concept analysis examined whether population data of lifetime heaviest alcohol consumption may be used to identify genetic loci that modulate risk.
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In Vivo Glutamate Measured with Magnetic Resonance Spectroscopy: Behavioral Correlates in Aging
To investigate the contribution of regional glutamate levels to behavior in the aging brain, we used an in vivo magnetic resonance spectroscopy protocol optimized for glutamate detection in 3 brain regions targeted by…
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Biomarkers—an Essential Tie That Binds the Future of Drugs and Diagnostics
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Alzheimer’s Disease Biomarkers: More Than Molecular Diagnostics
This review assesses progress in a number of areas of AD biomarker discovery and development, constituting a potential systems approach to understanding and diagnosing this disease.
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Assessment of Cardiac Biomarkers in Cynomolgus Macaques
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Serum Biomarkers Reveal Long-Term Cardiac Injury in Isoproterenol-Treated African Green Monkeys
We have used filter-aided sample preparation (FASP) and tandem mass tag (TMT) labeling to investigate serum protein alterations in isoproterenol-treated African green monkeys.
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Almorexant Promotes Sleep and Exacerbates Cataplexy in a Murine Model of Narcolepsy
The current study was designed to evaluate the hypnotic and cataplexy-inducing efficacy of a Hcrt antagonist in an animal model with low Hcrt tone and compare the ALM efficacy profile…