Biomedical sciences publications
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In Silico Systems Biology Approaches for the Identification of Antimicrobial Targets
We have compiled software tools and databases that are typically used for target identification through in silico analyses. We have also identified enzyme- and broad-spectrum metabolite-based drug targets that have…
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Bed Bug Detection: Current Technologies and Future Directions
Industry surveys report a 100-fold increase in calls for bed bug control, and almost all pest control operations currently respond to bed bug problems.
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Visual Search and the Aging Brain: Discerning the Effects of Age-Related Brain Volume Shrinkage on Alertness, Feature Binding, and Attentional Control
Poorer conjunction, but not feature, search performance was related to older age and volume shrinkage of nodes in the dorsolateral processing stream.
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Cytotoxic Monacolin Analogs from Monascus Purpureus-Fermented Rice
Two new monacolin analogs, monacolins O (1) and P (2), along with three known analogs, have been isolated from the ethanolic extract of Monascus purpureus-fermented rice.
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Incorrect ICBM-DTI-81 Atlas Orientation and White Matter Labels
Unfortunately, in our work using this atlas, we have encountered several substantial problems in terms of (a) correctness of spatial orientation and (b) correctness of white matter tract labels.
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The Tissint Martian Meteorite as Evidence for the Largest Impact Excavation
Here we show that the Tissint meteorite, a 2011 meteorite fall, contains virtually all the high-pressure phases (seven minerals and two mineral glasses) that have been reported in isolated occurrences…
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Characterization of a Diffusible Signaling Factor from Xylella Fastidiosa
We describe here the isolation and characterization of an X. fastidiosa DSF (XfDSF) as 2(Z)-tetradecenoic acid. This compound was isolated both from recombinant Erwinia herbicola expressing X. fastidiosa rpfF and…
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A Mechanism of Rapidly Reversible Cerebral Ventricular Enlargement Independent of Tissue Atrophy
Here, multimodal imaging, incorporating structural MRI, MRS, and DWI, was used in rats exposed to binge ethanol to provide insight into a mechanism of reversible ventricular enlargement.
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Understanding the Sleep-Wake Cycle: Sleep, Insomnia, and the Orexin System
Andrew D. Krystal, MD, MS, gathered a panel of experts in the area of the sleep-wake cycle and insomnia to review recent research and advances in understanding, current treatments for…
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Remapping the Brain to Compensate for Impairment in Recovering Alcoholics
We tested whether previously published functional magnetic resonance imaging data acquired in 15 recovering alcoholics and 15 controls at rest and while performing a spatial working memory task would fulfill…
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Modulation of the Cannabinoid Receptors by Hemopressin Peptides
The exciting finding of endocannabinoid system modulation by the nonapeptide hemopressin and its N-terminal extensions has highlighted the complexity of cannabinoid biology and pharmacology and sparked interest for therapeutic purposes.
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Targeting Glioblastoma Stem Cells: Cell Surface Markers
In this review, we primarily summarize recent advances in identification of GSC markers, with a particular focus on cell surface markers.