Biomedical sciences publications
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Impact of X Chromosome Genes in Explaining the Excess Risk of Cancer in Males
The authors examined cancer incidence sex ratios in Denmark for 1943–2003 by age group. At nongenital/nonbreast sites, incidences were consistently higher in males.
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Modulation of Luciferase Activity Using High Intensity Focused Ultrasound in Combination with Bioluminescence Imaging, Magnetic Resonance Imaging and Histological Analysis in Muscle Tissue
This study investigates the effect of high intensity focused ultrasound (HIFU) to muscle tissue transfected with a luciferase reporter gene under the control of a CMV-promoter.
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Genetic and Environmental Influences on the Ratio of 3’Hydroxycotinine to Cotinine in Plasma and Urine
This analysis sought to conduct a combined genetic epidemiologic and pharmacogenetic investigation of the 3HC/COT ratio in plasma and urine.
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Pharmacokinetics of Nikkomycin Z After Single Rising Oral Doses
Nikkomycin Z is an antifungal drug that inhibits chitin synthase. This agent is under development as an orphan product for treatment of coccidioidomycosis.
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Simultaneous Quantification of Perfusion and Permeability in the Prostate Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging with an Inversion-Prepared Dual-Contrast Sequence
The aim of the present study was to quantify both perfusion and extravasation in the prostate to discriminate tumor from healthy tissue, which might be achieved by dynamic contrast-enhanced magnetic…
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Degradation of Association and Projection White Matter Systems in Alcoholism Detected with Quantitative Fiber Tracking
Alcoholism affected FA and diffusivity, particularly λT, of several fiber bundles. Frontal and superior sites (frontal forceps, internal and external capsules, fornix, and superior cingulate and longitudinal fasciculi) showed greatest…
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Development of a Transillumination Infrared Modality for Differential Vasoactive Optical Imaging
We present the development and implementation of a new near infrared transillumination imaging modality for tissue imaging. Exogenous inhaled hyperoxic and hypercarbic gases are used as "vasoactive contrast agents" via…
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Bead-Based Mosaicing of Single Plane Illumination Microscopy Images Using Geometric Local Descriptor Matching
Existing intensity-based registration techniques still struggle to robustly and accurately align images that are characterized by limited overlap and/or heavy blurring. To be able to register such images, we add…
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Integrated Analysis of Breast Cancer Cell Lines Reveals Unique Signaling Pathways
We mapped genomic, transcriptional and proteomic profiles for 30 breast cancer cell lines onto a curated Pathway Logic symbolic systems model of EgfR-MAPK signaling.
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Postnatal Estradiol Up-Regulates Lung Nitric Oxide Synthases and Improves Lung Function in Bronchopulmonary Dysplasia
Fetal estradiol levels increase during late gestation and estradiol up-regulates NOS, suggesting that after preterm birth estradiol deprivation causes attenuated lung NOS resulting in impaired pulmonary function.
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The Leukocytes Expressing DARPP-32 are Reduced in Patients with Schizophrenia and Bipolar Disorder
Bipolar disorder (BPD) and schizophrenia (SCZ) are severe disorders representing an enormous social, familiar and individual burden, being SCZ the most disabling psychiatric disorder characterized by psychosis and cognitive impairment.
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Selective Loss of Gabab Receptors in Orexin-Producing Neurons Results in Disrupted Sleep/Wakefulness Architecture
Here we analyze the in vivo and in vitro phenotype of mice lacking the GABAB1 gene specifically in orexin neurons (oxGKO mice) and demonstrate that GABAB receptors on orexin neurons are essential in stabilizing and consolidating sleep/wake…