Biomedical sciences publications
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Tobacco Addiction and Pharmacogenetics of Nicotine Metabolism
This paper presents a brief overview of several components of tobacco addiction, including a discussion of progress towards the development of a comprehensive understanding of the pharmacogenetics of tobacco addiction…
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Blocking the Effects of MCP-1 Using a New Small Molecule Antagonist SR16951 for the Treatment of Autoimmune Diseases
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Protein Expression Changes in Prefrontal Cortex, Corpus Callosum, and Anterior Dorsal Cerebellum After Ethanol Exposure in Wistar Rats
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Evoked K-Complex Amplitude Is a Sensitive Marker of Adult Brain Aging
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Adenosinergic and Dopaminergic Signaling as Targets for Wake-Promoting Therapeutics: Insights from Mouse Genetic Models
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Neuroimaging of the Wernicke-Korsakoff Syndrome
Presented is the neuroradiological signature of acute Wernicke's encephalopathy (WE), derived from different types of magnetic resonance imaging (MRI) sequences.
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Opioidergic Projections to Sleep-Active Neurons in the Ventrolateral Preoptic Nucleus
We hypothesized that the influence of opiates on sleep may be mediated, at least in part, by the ventrolateral preoptic nucleus (VLPO), a key cell group for producing behavioral sleep.
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Global-Local Interference Is Related to Callosal Compromise in Alcoholism: a Behavior-DTI Association Study
We used a global–local paradigm to assess component processes of visuospatial ability and MR diffusion tensor imaging (DTI) to examine whether alcoholism-related microstructural degradation of the corpus callosum contributes to…
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Correlation of Population Parameters Leading to Power Differences in Association Studies with Population Stratification
We implemented a genetic model for population-based association studies with stratified samples and evaluated the impact on power with different genetic scenarios.
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New Developments in Sleep Research: Molecular Genetics, Gene Expression, and Systems Neurobiology
This mini-symposium review highlights some recent developments at the gene, molecular, cellular, and systems levels that have advanced this field.
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Rapid Alterations in Cortical Protein Profiles Underlie Spontaneous Sleep and Wake Bouts
Preliminary microarray analyses show that changes in behavioral state influence regional mRNA profiles; however, the impact of sleep on protein signatures is virtually unexplored. In these studies, cortical protein profiles…
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A Pilot Evaluation of a Nasal Expiratory Resistance Device for the Treatment of Obstructive Sleep Apnea
The present pilot study tests the hypothesis that the application of expiratory resistance via a nasal valve device would improve breathing during sleep in subjects with OSA and in primary…