Biomedical sciences publications
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Electrophysiological characterization of sleep/wake, activity and the response to caffeine in adult cynomolgus macaques
We sought to define basal sleep characteristics, sleep/wake architecture and electroencephalographic activity in a diurnal non-human primate (NHP) to evaluate the utility of this species for pharmacological manipulation of the…
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Modular Antigen-Specific T-cell Biofactories for Calibrated In Vivo Synthesis of Engineered Proteins
An artificial cell-signaling pathway is developed that capitalizes on the T-cell’s innate extravasation ability and transforms it into a vector for synthesizing calibrated amounts of engineered proteins in vivo.
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Development of a biodosimeter for radiation triage using novel blood protein biomarker panels in humans and non-human primates
We are developing a rapid screening method to assess whether an individual received an absorbed dose of ≥2 Gy based on the analysis of a specific panel of blood proteins in…
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Parallel Arousal Pathways in the Lateral Hypothalamus
We performed chemogenetic excitation of LH neurons in mice and observed increased wakefulness that lasted more than 4 h without unusual behavior or EEG anomalies.
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Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120
We are continuing our concerted effort to optimize our first lead entry antagonist, NBD-11021, which targets the Phe43 cavity of the HIV-1 envelope glycoprotein gp120, to improve antiviral potency and…
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Deletion of Trace Amine-Associated Receptor 1 Attenuates Behavioral Responses to Caffeine
Here, we report that locomotor and EEG spectral responses to the psychostimulants modafinil and caffeine are attenuated in TAAR1 KO mice.
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Cortical nNOS/NK1 Receptor Neurons Are Regulated by Cholinergic Projections From the Basal Forebrain
Cholinergic (ACh) basal forebrain (BF) neurons are active during wakefulness and rapid eye movement (REM) sleep and are involved in sleep homeostasis.
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Sleep/Wake Physiology and Quantitative Electroencephalogram Analysis of the Neuroligin-3 Knockout Rat Model of Autism Spectrum Disorder
Here, we evaluated sleep/wake physiology and behavioral phenotypes of rats with genetic ablation of Nlgn3.
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Plasticity-Related Gene Expression During Eszopiclone-Induced Sleep
We used the expression of plasticity-related genes to assess synaptic plasticity changes during drug-induced sleep.
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Editorial Overview: Neurobiology of Sleep 2017
This issue of 'Current Opinion of Neurobiology' highlights some of the new research insights into sleep/wake control and sleep function afforded by this expanded research armamentarium.
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Trace Amine-Associated Receptor 1 Regulates Wakefulness and EEG Spectral Composition
We used Taar1 knockout and overexpressing mice and TAAR1 agonists to elucidate the role of TAAR1 in sleep/wake. EEG, EMG, body temperature, and locomotor activity were recorded in Taar1 KO,…
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Trace Amine-Associated Receptor 1 Agonists as Narcolepsy Therapeutics
As partial agonists at trace amine-associated receptor 1 (TAAR1) promote wakefulness in mice and rats, we evaluated whether TAAR1 agonism had beneficial effects in two mouse models of narcolepsy.