Biomedical sciences publications

Here we discover that the spliceosome is a new target of oncogenic stress in MYC-driven cancers. We identify BUD31 as a MYC-synthetic lethal gene in human mammary epithelial cells, and…

We report that the spliceosome modulator sudemycin induces selective cytotoxicity in primary chronic lymphocytic leukemia (CLL) cells when compared with healthy lymphocytes and tumor cells from other B-lymphoid malignancies, with…

Here, we show that a dose of SR-2P administered 24 h prior to infection provides some protection against the virus, but to a lesser degree than SR-2P administered either once…

The Total Exposure Study was designed to estimate levels of biomarkers of tobacco-specific and non-specific exposure and of potential harm in U.S. adult current cigarette smokers and tobacco product non-users.

This chapter focuses on some promising translational cognitive paradigms for use in rodents, non-human primates, and humans.

Given the complexity of sensorimotor integration invoked to maintain upright posture, the integrity of supratentorial brain structures may also contribute to quiet standing and consequently be vulnerable to interference from…

Objective- To assess if the allelic variations of rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene cluster are associated with smoking cessation after nicotine replacement therapy (NRT).

The purpose of this meeting is to provide fundamental insights on brain mechanisms that contribute to the recovery from alcohol dependence. Ultimately, it is to promote studies in understanding neurobiological…

The objective of the study was to assess the impact of menstrual cycle phase on the polysomnogram and electroencephalographic (EEG) features of sleep in midlife women.

The preclinical characterization of this highly promising ligand comprised the evaluation of its in vitro properties, including microsomal, plasma, and gastrointestinal fluid stability, cytochrome P450 inhibition, plasma protein binding, and…

We evaluated whether alcohol consumption was prospectively associated with CAD mortality risk independent of familial factors.