Biomedical sciences publications
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Self-Reported Depressive Symptoms Are Associated with Cognitive Compromise and Poorer Life Functioning in Alcoholism, Hiv and Their Comorbidity
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Sleep-Active Cells in the Cerebral Cortex and Their Role in Slow-Wave Activity
We recently identified neurons in the cerebral cortex that become activated during sleep episodes with high slow-wave activity (SWA).
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How Modulation of Functional Connectivity Between Limbic and Frontocerebellar Circuits from Rest to Task Enables Alcoholics to Recognize Who Is Who
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Sleep-Active Neuronal Nitric Oxide Synthase-Positive Cells of the Cerebral Cortex: a Local Regulator of Sleep?
We review the possible functions of neuronal nitric oxide synthase in regulating neuronal activity, synaptic plasticity and cerebral blood flow within the context of local sleep regulation in the cerebral…
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Aggressive and Chronic Periodontitis Correlate with Distinct Cellular Sources of Key Immunoregulatory Cytokines
We aimed to investigate the expression of adhesion molecules and the source of proinflammatory and anti-inflammatory cytokines in circulating mononuclear cells from patients with CP and AP.
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Computational Databases, Pathway and Cheminformatics Tools for Tuberculosis Drug Discovery
Cheminformatic techniques have been leveraged and are examined in this review. We suggest that these computational approaches should be optimally integrated within a workflow with experimental approaches to accelerate TB…
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In Vivo MRSI of Hyperpolarized [1-13C]Pyruvate Metabolism in Rat Hepatocellular Carcinoma
We implemented a three-dimensional MRSI sequence to investigate this potential hallmark of cellular metabolism in rat livers bearing HCC (n = 7 buffalo rats).
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Diamino-1,2,4-Triazole Derivatives Are Selective Inhibitors of Tyk2 and Jak1 Over Jak2 and Jak3
Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1–3.
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Neurocircuitry of Emotion and Cognition in Alcoholism: Contributions from White Matter Fiber Tractography
An understanding of the role of cortico-limbic fiber degradation in emotional dysregulation in alcoholism is now emerging.
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Captopril Increases the Intensity of Monocyte Infection By Trypanosoma Cruzi and Induces Human T Helper Type 17 Cells
Here we showed that captopril increases the intensity of T. cruzi infection of human monocytes in vitro. The increased parasitism was accompanied by up-regulated expression of ACE in human monocytes.
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Fiber Tracking Functionally Distinct Components of the Internal Capsule
To examine the microstructural condition of this fiber system and to test functional correlates of its sectors in health and aging, adults were examined with diffusion tensor imaging fiber tracking…
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A. Diamino-1,2,4-Triazole Derivatives are Selective Inhibitors of TYK2 and JAK1 Over JAK2 and JAK3
Presented is the design and synthesis of 1,2,4-triazoles, and the evaluation of their inhibitory activity against the Janus associated kinases TYK2 and JAKs 1–3.