Biomedical sciences publications

Here, feasibility and safety of α-synuclein suppression were evaluated by treating monkeys with small interfering RNA (siRNA) directed against α-synuclein.

The protein α-synuclein is involved in the pathogenesis of Parkinson's disease and other neurodegenerative disorders.

The research and development (R&D) process that ultimately leads to effective drugs is exceedingly difficult, and often the public does not understand the drug discovery pipeline.

C57Bl6-lacZ animals were exposed to a range of low dose-rate simulated solar particle event (sSPE) radiation at the NASA-sponsored Research Laboratory (NSRL) at Brookhaven National Laboratory (BNL).

SR16157 is a novel dual-acting inhibitor of estrogen action that irreversibly inhibits the estrogen biosynthetic enzyme steroid sulfatase and releases the selective estrogen receptor modulator SR16137, which blocks the estrogen…

The objective of these studies was to better understand the source of low oral exposure and to develop a formulation that could be used in preclinical development studies.

Magnetic resonance and diffusion tensor imaging data were acquired and midsagittal area, length, dorsoventral height, fractional anisotropy, and mean diffusivity of the total corpus callosum and volume of the lateral…

Pythium ultimum is a ubiquitous oomycete plant pathogen responsible for a variety of diseases on a broad range of crop and ornamental species.

We performed association studies with 5,151 SNPs that were judged as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN) based on location under reported linkage peaks, previous results…

A prototype stationary source for medical imaging is evaluated. X-ray focal spot diameters of less than 0.2 mm are formed with beam currents of up to 75 mA at beam…

We used an established model of brain tumor (glioma) development in the offspring of rats exposed prenatally to the mutagen N-ethyl-N-nitrosourea.

Using a systematic immediate-early gene (IEG) mapping to detect neuronal activation, the consequences of SD were mapped primarily to forebrain regions.