Biomedical sciences publications
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Global Reemergence of Tuberculosis: Are Host Defense Peptides an Option to Ameliorate Disease Burden?
Intermittent drug therapy due to noncompliance or poor delivery of therapy promotes the emergence of bacterial strains showing resistance to multiple drugs and the rise of extremely drug-resistant strains.
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Orally Bioavailable Anti-HBV Dinucleotide Acyloxyalkyl Prodrugs
The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs…
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Discovery of 1-[3-(4-Bromo-2-Methyl-2H-Pyrazol-3-Yl)-4-Methoxyphenyl]-3-(2, 4-Difluorophenyl)Urea (Nelotanserin) and Related 5-Hydroxytryptamine 2A Inverse Agonists for the Treatment of Insomnia
We describe here a series of 5-HT2A inverse-agonists that when dosed in rats, both consolidate the stages of NREM sleep, resulting in fewer awakenings, and increase a physiological measure of sleep…
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T2 Relaxation Times of 13C Metabolites in a Rat Hepatocellular Carcinoma Model Measured in Vivo Using 13C-MRS of Hyperpolarized [1-13C]Pyruvate
Following hyperpolarized [1-13C]pyruvate injections, pyruvate and its metabolic products, alanine and lactate, were observed in the liver of five rats with hepatocellular carcinoma and five healthy control rats.
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Biomimetic Actinide Chelators: an Update on the Preclinical Development of the Orally Active Hydroxypyridonate Decorporation Agents 3,4,3-Li(1,2-HOPO) and 5-LIO(Me-3,2-HOPO)
A perspective on the preclinical development of two hydroxypyridonate actinide decorporation agents, 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO), is presented. The chemical syntheses of both candidate compounds have been optimized for scale-up.
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Do Evoked Potential Differences Reflect a Deficit in Those Suffering a Sleep Disorder, or Resilience in Those Who Can Avoid It?
The novel approach taken by Gumenyuk and colleagues in this issue of SLEEP1 has produced interesting and novel data about SWSD, specifically, the absence of a difference in N1, the appearance…
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Graded Brain Abnormalities in Alcoholics with and Without Signs of Wernicke Encephalopathy
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Pontocerebellar Volume Deficits and Ataxia in Alcoholic Men and Women: No Evidence for “Telescoping”
Whether women are more vulnerable to brain dysmorphology than men despite lower alcohol consumption levels or shorter dependency remains controversial and has not been considered with respect to infratentorial structures…
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Time-Frequency Analysis of Visual and Auditory Nogo Event Related Potentials in Alcoholic Women
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Trypanosoma Cruzi-Induced Activation of Functionally Distinct Alpha Beta and Gamma Delta CD4(-) CD8(-) T Cells in Individuals with Polar Forms of Chagas’ Disease
In this work, we sought to investigate whether αβ or γδ DN T cells display distinct immunoregulatory potentials in patients with polar forms of human Chagas' disease.
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Hyperpolarized (13)C MRSI for Therapeutic Response Monitoring of Prostate Cancer to Radiotherapy
In this technique, the transient fate of pyr and its downstream metabolites lactate (lac), alanine, and bicarbonate is measured with 13C Magnetic Resonance Spectroscopy Imaging (MRSI) following an injection of hyperpolarized…
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In Situ Chemical Analyses By Underwater Mass Spectrometry