Biomedical sciences publications
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SU11248 (Sunitinib) Directly Inhibits the Activity of Mammalian 5′-AMP-Activated Protein Kinase (AMPK)
Here we report that the chemotherapeutic drug SU11248 (sunitinib) is at least as potent an inhibitor of AMPK as compound C, which is a commonly used experimental direct inhibitor of…
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Patterns of Gene Expression in the Ductus Arteriosus Are Related to Environmental and Genetic Risk Factors for Persistent Ductus Patency
Three independent risk factors are associated with patent ductus arteriosus that fail to close during prostaglandin inhibition.
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Alcohol’s Effects on Brain and Behavior
One main area of this research has focused on the neuropsychological sequelae of alcoholism, which has resulted in the description of a pattern of sparing and impairment that provided an…
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Biomimetic Actinide Chelators: an Update on the Preclinical Development of the Orally Active Hydroxypyridonate Decorporation Agents 3,4,3-Li(1,2-HOPO) and 5-LIO(Me-3,2-HOPO)
A perspective on the preclinical development of two hydroxypyridonate actinide decorporation agents, 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO), is presented. The chemical syntheses of both candidate compounds have been optimized for scale-up.
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Do Evoked Potential Differences Reflect a Deficit in Those Suffering a Sleep Disorder, or Resilience in Those Who Can Avoid It?
The novel approach taken by Gumenyuk and colleagues in this issue of SLEEP1 has produced interesting and novel data about SWSD, specifically, the absence of a difference in N1, the appearance…
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Graded Brain Abnormalities in Alcoholics with and Without Signs of Wernicke Encephalopathy
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Pontocerebellar Volume Deficits and Ataxia in Alcoholic Men and Women: No Evidence for “Telescoping”
Whether women are more vulnerable to brain dysmorphology than men despite lower alcohol consumption levels or shorter dependency remains controversial and has not been considered with respect to infratentorial structures…
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Time-Frequency Analysis of Visual and Auditory Nogo Event Related Potentials in Alcoholic Women
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Trypanosoma Cruzi-Induced Activation of Functionally Distinct Alpha Beta and Gamma Delta CD4(-) CD8(-) T Cells in Individuals with Polar Forms of Chagas’ Disease
In this work, we sought to investigate whether αβ or γδ DN T cells display distinct immunoregulatory potentials in patients with polar forms of human Chagas’ disease.
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SR16157 Is a Potent Dual-Acting Inhibitor of Estrogen Biosynthesis and Estrogen Receptor
Using in vitro and xenograft MCF-7 breast cancer models, we demonstrated that SR16157 inhibited STS activity, cell growth, and estrogenic functions and that SR16137 reduced expression of estrogen-regulated genes with greater potency…
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Perception of Mercury Contamination By Brazilian Adolescents in a Gold Mining Community: An Ethnographic Approach
This study used ethnographic methods to examine the perception of mercury contamination by adolescents in the mining community of Poconé, Mato Grosso, Brazil.
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Contribution of Regional White Matter Integrity to Visuospatial Construction Accuracy, Organizational Strategy, and Memory for a Complex Figure in Abstinent Alcoholics
Visuospatial construction ability as used in drawing complex figures is commonly impaired in chronic alcoholics, but memory for such information can be enhanced by use of a holistic drawing strategy…